A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model

Preventive effect of nasal filters on allergic rhinitis: A randomized, double-blind, placebo-controlled crossover park study

“…When looking at results from other park studies with similar study periods, the filters' efficacy appears to compare positively with the efficacy found for antihistamines, 20,22 intranasal steroid sprays, 21,23 mast cell inhibitors, 24 and combination therapies. 25,26 In relation to placebo, these studies found first-day efficacies ranging from favoring placebo to roughly 50% improvements in symptoms.…”

“…This could prove important for patients because drowsiness is a well-known side effect to many antihistamines. 20,22,25,26 The nasal filter's positive effect on drowsiness and global discomfort increased when looking solely at the groups with baseline TNSSs of 0 or 1 (Table IV). These findings further underline the added benefit of initiating use of the filters before symptom onset.…”

Azelastine hydrochloride:a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability

“…Although azelastine nasal spray controlled symptoms when administered as needed, such treatment did not reduce allergic inflammation. Taste disturbances and twice-daily dosing associated with azelastine nasal spray might affect compliance; however, rates of treatment discontinuation ascribed to taste dis turbances or noncompliance were similar with azelastine and placebo in well-controlled clinical studies [52][53][54][55][56] .…”

“…Two 2-day outdoor studies were conducted in city parks during the fall allergy season of 1989 to determine dose-ranging and the onset and duration of action of azelastine nasal spray 52,53 . As with the long-term studies, the TSC and MSC severity scores were used to evaluate the dosage groups.…”

Azelastine HCl: A Review of the Old and New Formulations

“…34,35 Both studies demonstrated that azelastine improved rhinitis symptoms within two hours after administration and lasted up to 24 hours suggesting that it could be administered once or twice a day.…”