A Dose‐Finding Study to Guide Use of Verapamil as an Adjunctive Therapy in Tuberculosis
Chandrasekaran Padmapriyadarsini,
John D. Szumowski,
Nabila Akbar
et al.
Abstract:Induction of mycobacterial efflux pumps is a cause of Mycobacterium tuberculosis (Mtb) drug tolerance, a barrier to shortening antitubercular treatment. Verapamil inhibits Mtb efflux pumps that mediate tolerance to rifampin, a cornerstone of tuberculosis (TB) treatment. Verapamil's mycobacterial efflux pump inhibition also limits Mtb growth in macrophages in the absence of antibiotic treatment. These findings suggest that verapamil could be used as an adjunctive therapy for TB treatment shortening. However, ve… Show more
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