A dose characterization study evaluating the pharmacodynamics and safety of a concentrated alfaxalone solution (4%) as an intramuscular sedative in dogs
Ting Michelle Angel Yvonne Hoon,
Irving Tjiah Wern Kat,
Kirby Pasloske
et al.
Abstract:Alfaxalone is a commonly employed veterinary anaesthetic induction and sedation agent. A 4% w/v preserved, aqueous formulation of alfaxalone ‘RD0387’ (A4%) has recently been developed. To evaluate the sedative effects of A4%, three doses, 5 mg kg−1 (A5); 7.5 mg kg−1 (A7.5) and 10 mg kg−1 (A10) were administered intramuscularly into the epaxial musculature of six healthy adult mixed‐breed dogs in an experimental, randomized, blinded, crossover study. Sedation time variables, quality of sedation (including onset… Show more
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