“…Activation by Myb of T-lymphocyte speci®c genes such as CD4, T cell receptor d and lck tyrosine kinase and of genes which function in cell growth control such as cdc2 and c-myc has also been demonstrated (Hernandez-Munain and Krangel, 1995;McCracken et al, 1994;Cogswell et al, 1993;Ku et al, 1993;Siu et al, 1992;Nakagoshi et al, 1992;Evans et al, 1990). The bcl-2 gene, which serves an antiapoptotic function in various cell types, has very recently been reported as a Myb target gene (Salomoni et al, 1997;Taylor et al, 1996;Frampton et al, 1996). Other transcription factors can cooperate with Myb to achieve maximal levels of transcriptional activation (Oelgeschlager et al, 1996;Dai et al, 1996;Hernandez-Munain and Krangel, 1995;Shapiro, 1995;McCracken et al, 1994;Burk et al, 1993;Ness et al, 1993), and thus may enhance transactivation of target genes and direct cellular speci®city.…”