A dolabellane diterpene from the Brazilian brown alga Dictyota pfaffii

Barbosa, Julianna Freires; Teixeira, Valéria Laneuville; Villaça, Roberto Campos; Pereira, Renato Crespo; Abrantes, Juliana L.; Frugulhetti, Izabel Christina Palmer da Paixão

doi:10.1016/s0305-1978(03)00120-0

Cited by 39 publications

(38 citation statements)

References 7 publications

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“…Although red algae are considered to be the most important source of many biologically active metabolites, brown algae have been shown to be a promising source as well. Dolabelladienotriol (1) is a minor natural product derived from Dictyota pfaffii, a Brazilian brown algae that grows on the Atol das Rocas reef, located in the State of Rio Grande do Norte in Northeastern Brazil (Barbosa et al, 2004). Studies in vitro have shown that this compound has low cytotoxicity and acts as a potent inhibitor of the HIV-1 replication cycle in primary cell cultures by inhibiting the Reverse Transcriptase (RT) enzyme.…”

Section: Introductionmentioning

confidence: 99%

“…Studies in vitro have shown that this compound has low cytotoxicity and acts as a potent inhibitor of the HIV-1 replication cycle in primary cell cultures by inhibiting the Reverse Transcriptase (RT) enzyme. It has also been shown to inhibit the initial replication of HSV-1 (Abrantes et al, 2010;Barbosa et al, 2004;Cirne-Santos et al, 2008;.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Garrido¹,

Teixeira²,

Teixeira³

et al. 2011

Rev. bras. farmacogn.

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Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Garrido¹,

Teixeira²,

Teixeira³

et al. 2011

Rev. bras. farmacogn.

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“…The opening of this region involves a large displacement of the aromatic side chains of Tyr181, Tyr188 and Trp229 and a rotation of the leaves β-β-12-13-β-14, resulting in a breakdown of the primer grip in the direction that the complex primertemplate moves during the subsequent incorporation of nucleotides (Das et al, 2004) (Figure 3). Our group showed that the diterpene 8,10,18-trihydroxy-2,6-dolabelladiene (THD, 5), obtained from the extract of Dictyota pfaffi or by reducing 10,18-diacetoxy-8-hydroxy-2,6-dolabelladiene (3), showed signifi cant antiviral activity, up to 3 times higher with this chemical modifi cation (Barbosa et al, 2003;Barbosa et al, 2004;Cirne-Santos et al, 2006). Our experimental study confi rmed a dose-dependent anti-HIV-1 TR activity, with an IC50 of 16.5 µM, inhibition levels ranging from 27% (3 μM) to 95% (100 μM), and 85% viability of peripheral blood mononuclear cells (PBMC) at concentrations of 200 μM (Barbosa et al 2003;Cirne-Santos et al, 2006).…”

Section: Terpenes As Nnrti Models: Looking At Future Anti-hiv Treatmementioning

confidence: 99%

HIV-1 Reverse Transcriptase: a potential target for marine products

Miceli¹,

Souza²,

Rodrigues³

et al. 2012

Rev. bras. farmacogn.

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HIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identifi cation of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strains, whose treatment options are already limited, putting at risk these individuals lives. The literature has recognized marine organisms and their products as natural sources for the identifi cation of new therapeutic options for different pathologies. In this brief review, we consider the structure of HIV-1 RT and its most common inhibitors, as well as some marine diterpenes originally reported as HIV-1 RT inhibitors to encourage the identifi cation and development of new marine antiviral prototypes.

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“…Green and brown algae have been classified with the compounds having antifungal and antimicrobial activities 4 .Seaweeds are of great interest in the biomedical area, mainly due to their contents of bioactive substrate which show great potential as antimicrobial, anti-inflammatory, antiviral 5 and anti-tumoral drugs 6,7 . The anti-cancerous, anti-obesity and anti-proliferative effects have been shown by the in vivo studies from the components of seaweeds 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Gelidiella Acerosa: A Precis

Sharma¹,

Tyagi²,

Kumar³

2017

Int. Res. J. Pharm.

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Seaweeds are the macrophytic algae that grows mostly in shallow waters and are highly beneficial. Gelidiella acerosa belongs to the division rhodophyta and is found in shallow waters of intertidal and upper sub tidal zone. It yields the best quality agar a nd is also used as an ingredient in milk products, jams, marmalades, calorie free cooking and ice-creams. Since it has been reported to contain high percentages of proteins, lipids, carbohydrates, polysaccharides, phenols and flavonoids, it has shown wide applications in pharmaceutical industry. Gelidiella acerosa is reported to possess many pharmacological activities such as anticancer, cytotoxicity, antimicrobial, antioxidant, anticholinesterase, antifertility and anticoagulation activities.

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A dolabellane diterpene from the Brazilian brown alga Dictyota pfaffii

Cited by 39 publications

References 7 publications

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

HIV-1 Reverse Transcriptase: a potential target for marine products

Gelidiella Acerosa: A Precis

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