“…15 Efficient synthetic tools such as multicomponent, tandem, domino and pericyclic reactions that work under mild conditions are particularly valuable in DOS because they support the use of orthogonal substrates with a wide range of functional groups that, through subsequent transformations, allow rapid construction of complex molecules in one reaction stage. 16 However, the application of one-pot processes based on the MCR-post transformation in DOS in a consecutive 17 or domino manner 13 a ,18 to generate scaffold diversity is underexplored. Additionally, these methods typically employ less-ecofriendly conditions such as high temperatures, use of metal catalysts, toxic solvents, and/or excessive amounts of reagents, and elongated reaction times.…”