A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania
Renana Fischer Weinberger,
Sabine Bachmaier,
Veronica Ober
et al.
Abstract:Parasitic protozoa of the genus Leishmania cycle between the phagolysosome of mammalian macrophages, where they reside as rounded intracellular amastigotes, and the midgut of female sand flies, which they colonize as elongated extracellular promastigotes. Previous studies indicated that protein kinase A (PKA) plays an important role in the initial steps of promastigote differentiation into amastigotes. Here, we describe a novel regulatory subunit of PKA (which we have named PKAR3) that is unique to Leishmania … Show more
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