A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome

López‐Lerma, Ingrid; Estrach, M.T.

doi:10.1016/j.jaad.2009.03.041

Cited by 12 publications

(5 citation statements)

References 42 publications

(34 reference statements)

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“…Aberrant cytokine production of helper T cells type 2 and low production of helper T cell type 1 cytokines are pathognomonic. This results in an impaired T cell response to mitogen which eventually leads to atypical progression of T cells [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Mycosis Fungoides Presentation in Emergency

Shujaa¹,

Suriya²

2011

TOEMJ

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Abstract:We present the case of a young lady who presented to the department of emergency medicine (DEM) for evaluation of painful breast swelling and skin indurations involving 90% of the body surface. She stayed long in the DEM for 3 days and managed for breast abscess she was consulted to dermatology for evaluation of skin lesions and preliminary diagnosed as rare skin T cell lymphoma. Final diagnosis based on clinical and histopathological was Mycosis Fungoids (MF).This case reveals that prompt referral from the DEM to the concerned speciality even for the rare type of diseases like MF can facilitate diagnosis and management and overall positive impact on disease outlook. Our patient was finally admitted under oncology unit and managed appropriately.

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Section: Discussionmentioning

confidence: 99%

Mycosis Fungoides Presentation in Emergency

Shujaa¹,

Suriya²

2011

TOEMJ

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“…A different adhesion molecule profile has been detected in patients with MF, demonstrating an increase in intercellular adhesion molecules ICAM‐1 and ICAM‐3. The detection of this profile in early stages of MF supports the theory that inflammation triggers a lymphoma, but future investigations that define with certainty whether these ICAMs may serve as disease activity markers in these patients are required 8 . Mycosis fungoides has been shown to affect quality of life in the visible, functional, and emotional domains, causing both fear of death and incapacity to work and carry out everyday activities 3 …”

Section: Introductionmentioning

confidence: 88%

Is PUVA maintenance therapy necessary in patients with early‐stage mycosis fungoides? Evaluation of a treatment guideline over a 28‐month follow‐up

et al. 2011

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“…ICAMs are also important in the pathogenesis of many skin disorders, such as cutaneous T-cell lymphoma, which shares important clinical and histological autoimmune features, playing a key role in the selective localization of T cells to the skin. Patients with this disease have high levels of sICAM-1 and sICAM-3 in the serum compared with healthy individuals or patients with inflammatory dermatosis [198,199]. sICAM-3 is also elevated in the sera of patients with psoriasis, another autoimmune dermatological disease [200].…”

Section: Autoimmunitymentioning

confidence: 98%

ICAMs in Immunity, Intercellular Adhesion and Communication

Guerra-Espinosa,

Jiménez-Fernández,

Sánchez-Madrid

et al. 2024

Cells

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Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and functional families involved in cell development, activation, differentiation and migration. Among them, β2 integrins (LFA-1, Mac-1, p150,95 and αDβ2) are predominantly involved in homotypic and heterotypic leukocyte adhesion. β2 integrins bind to intercellular (I)CAMs, actin cytoskeleton-linked receptors belonging to immunoglobulin superfamily (IgSF)-CAMs expressed by leukocytes and vascular endothelial cells, enabling leukocyte activation and transendothelial migration. β2 integrins have long been viewed as the most important ICAMs partners, propagating intracellular signalling from β2 integrin-ICAM adhesion receptor interaction. In this review, we present previous evidence from pioneering studies and more recent findings supporting an important role for ICAMs in signal transduction. We also discuss the contribution of immune ICAMs (ICAM-1, -2, and -3) to reciprocal cell signalling and function in processes in which β2 integrins supposedly take the lead, paying particular attention to T cell activation, differentiation and migration.

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A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome

Cited by 12 publications

References 42 publications

Mycosis Fungoides Presentation in Emergency

Mycosis Fungoides Presentation in Emergency

Is PUVA maintenance therapy necessary in patients with early‐stage mycosis fungoides? Evaluation of a treatment guideline over a 28‐month follow‐up

ICAMs in Immunity, Intercellular Adhesion and Communication

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