A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life

Berry, Cristine E.; Billheimer, Dean; Jenkins, Isaac C.; Lu, Zhenqiang; Stern, Debra A.; Gerald, Lynn B.; Carr, Tara F.; Guerra, Stefano; Morgan, Wayne J.; Wright, Anne L.; Martínez, Fernando D.

doi:10.1164/rccm.201604-0753oc

Cited by 158 publications

(162 citation statements)

References 28 publications

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“…Many studies have suggested that children with an episode of RSV-related bronchiolitis in infancy are more likely to have recurrent wheeze [3,16], especially if their bronchiolitis was severe [17]. Followed up over time, these children have spirometric values consistent with reduced airway patency at school age [4,16,18]. A similar association has been found for HRV-related bronchiolitis, too [19].…”

Section: Discussionmentioning

confidence: 60%

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Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Barlotta

Pirillo

Stocchero

et al. 2018

The Journal of Infectious Diseases

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Background. Bronchiolitis is associated with a greater risk of developing recurrent wheezing, but with currently available tools, it is impossible to know which infants with bronchiolitis will develop this condition. This preliminary prospective study aimed to assess whether urine metabolomic analysis can be used to identify children with bronchiolitis who are at risk of developing recurrent wheezing.Methods. Fifty-two infants <1 year old treated in the emergency department at University Hospital of Padova for acute bronchiolitis were enrolled (77% tested positive for respiratory syncytial virus [RSV]). Follow-up visits were conducted for 2 years after the episode of bronchiolitis. Untargeted metabolomic analyses based on mass spectrometry were performed on urine samples collected from infants with acute bronchiolitis. Data modeling was based on univariate and multivariate data analyses.Results. We distinguished children with and those without postbronchiolitis recurrent wheeze, defined as ≥3 episodes of physician-diagnosed wheezing. Pathway overrepresentation analysis pointed to a major involvement of the citric acid cycle (P < .001) and some amino acids (lysine, cysteine, and methionine; P ≤ .015) in differentiating between these 2 groups of children.Conclusion. This is the first study showing that metabolomic profiling of urine specimens from infants with bronchiolitis can be used to identify children at increased risk of developing recurrent wheezing.

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Section: Discussionmentioning

confidence: 60%

“…Recently, a birth cohort study that has been ongoing for almost 4 decades showed that respiratory syncytial virus (RSV) infection of the lower respiratory tract during early life is associated with a persistently low trajectory of lung function that represents an important pathway to chronic obstructive pulmonary disease [4].…”

mentioning

confidence: 99%

Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Barlotta

Pirillo

Stocchero

et al. 2018

The Journal of Infectious Diseases

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“…13 In further follow up, 599 subjects showed a stable, low lung function trajectory from age 11 to 32, with spirometry taken every 4–6 years. 14 These studies demonstrate that when low lung function accompanies childhood asthma, that low lung function tends to persist into adulthood.…”

Section: Childhood Cohortsmentioning

confidence: 85%

Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease

McGeachie

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of Review This review will catalog the many recent longitudinal studies that have investigated the relationship between asthma and lung function, or the persistence and trajectories of lung function deficits. Recent Findings Recent work has reported on 50-year follow-ups of some prominent population cohorts. A history of asthma confers a 10-to-30 fold risk of chronic obstructive pulmonary disease. Subjects reaching a reduced maximum growth of FEV1 in early adulthood are at risk for early or more severe COPD. Summary Taken together, there is a wealth of overlapping cohort studies of lung function, asthma, and COPD. These show that asthma is associated with reduced lung function, which may start in infancy or prenatally, persist through childhood and adulthood, and predispose for early or more severe COPD.

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“…Most asthmatics start wheezing in early childhood . Patients with COPD may have early life symptoms and airflow obstruction, and there are associations between COPD‐associated genes and transient early symptoms of wheeze …”

Section: Introductionmentioning

confidence: 99%

“…4 Most asthmatics start wheezing in early childhood. 5,6 Patients with COPD may have early life symptoms and airflow obstruction, 7,8 and there are associations between COPD-associated genes and transient early symptoms of wheeze. 8 Currently, it is difficult to predict if early childhood wheeze will remit or is the precursor of persistent wheezing/asthma.…”

Section: Introductionmentioning

confidence: 99%

SERPINA1 gene polymorphisms in a population‐based ALSPAC cohort

DeLuca

Poluzioroviene

Taminskienė

et al. 2019

Pediatric Pulmonology

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Background There is an association between persistent preschool wheezing phenotypes and school‐age asthma. These wheezing/asthma phenotypes likely represent clinical entities having specific genetic risk factors. The SERPINA1 gene encodes α 1‐antitrypsin (AAT), and mutations in the gene are important in the pathophysiology of pulmonary diseases. We hypothesized that there might be an association between SERPINA1 gene polymorphisms and the risk of developing wheezing/school age asthma. Objective To examine 10 single nucleotide polymorphisms (SNPs) of SERPINA1 (rs6647, rs11832, rs17580, rs709932, rs1243160, rs2854254, rs8004738, rs17751769, rs28929470, and rs28929474) and relate them to childhood wheezing phenotypes and doctor‐diagnosed asthma in the population‐based Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Methods Wheeze data, reports of physician‐diagnosed asthma and data on the SERPINA1 gene SNPs, were available for 7964 children. Binary logistic regression was used to assess the associations between allele prevalence and wheezing and asthma phenotypes. P values were adjusted to account for multiple hypotheses using the Benjamini‐Hochberg false discovery rate. Results Only within a subgroup of children with asthma who had no prior diagnosis of preschool wheeze was there a trend for association between rs28929474 (Glu342Lys, Pi*Z causing AAT deficiency; P = .0058, adjusted P = .058). No SNP was associated with wheezing and asthma in those with preschool wheeze. Conclusion Analyzed SNPs in SERPINA1 are not associated with wheezing/asthma phenotypes. Only rs28929474, the most common pathologic SNP (Pi*Z) in the SERPINA1 gene, might be associated with a risk of developing school‐age asthma without exhibiting preschool wheeze.

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A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life

Abstract: A distinct group of individuals in a nonselected population demonstrates a persistently low lung function trajectory that may be partly established at birth and predisposes them to chronic obstructive pulmonary disease later in life.

Cited by 158 publications

References 28 publications

Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease

SERPINA1 gene polymorphisms in a population‐based ALSPAC cohort

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