A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons

Katsurabayashi, Shutaro; Kubota, Hidekazu; Tokutomi, Naofumi; Akaike, Norio

doi:10.1016/s0028-3908(03)00103-5

Cited by 70 publications

(61 citation statements)

References 27 publications

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“…m-chlorophenylbiguanide, a 5-HT(3) agonist, presynaptically facilitated GABA release (Katsurabayashi et al, 2003). These actions are likely related to its anxiolytic effects.…”

Section: Discussionmentioning

confidence: 97%

“…The pharmacological effects of buspirone on GAT1 À/À mice together with the results of fluoxetine and amitriptyline further suggest alterations to the serotonergic system of the mutant mice. These might be explained by complex interactions between GABAergic and serotonergic systems (Katsurabayashi et al, 2003;Tao and Auerbach, 2000). Serotonin release could be regulated by GABA in brain.…”

Section: Discussionmentioning

confidence: 99%

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Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

Liu

Cai

et al. 2006

Neuropsychopharmacol

117

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g-Aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contributions of the GAT1 in regulating mental status are not fully understood. In this paper, we observed the behavioral alterations of GAT1 knockout (GAT1 À/À ) mice using several depressionand anxiety-related models (eg, the forced-swimming test and the tail-suspension test for testing depression-related behaviors; the openfield test, the dark-light exploration test, the emergence test, and the elevated plus maze (EPM) test for anxiety-related behaviors). Here we found that GAT1 À/À mice showed a lower level of depression-and anxiety-like behaviors in comparison to wild-type mice. Furthermore, GAT1 À/À mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail-suspension test and/or the EPM test. Moreover, the basal level of corticosterone was found to be significantly lower in GAT1 À/À mice. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice.

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“…m-chlorophenylbiguanide, a 5-HT(3) agonist, presynaptically facilitated GABA release (Katsurabayashi et al, 2003). These actions are likely related to its anxiolytic effects.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

Liu

Cai

et al. 2006

Neuropsychopharmacol

117

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“…Similarly, presynaptic inhibition of GABA release is mediated by 5-HT 1A [90,95,96] and 5-HT 1B receptors [88,117]. By activation of 5-HT 3 receptors, instead, 5-HT stimulates the release of either glutamate [7,57,185] or GABA [90,96,179]. Also 5-HT 2 receptors were shown to stimulate GABA release [2] and to either increase [2,72,177] or reduce [118] glutamate release in distinct structures.…”

Section: Modes Of Interactionmentioning

confidence: 99%

“…At a pre-synaptic level, 5-HT can modulate neurotransmitter release: for example, in various brain regions glutamate release is reduced by 5-HT 1A [162,164,177], 5-HT 1B [13,130,151,167] and 5-HT 6 receptors [31]. Similarly, presynaptic inhibition of GABA release is mediated by 5-HT 1A [90,95,96] and 5-HT 1B receptors [88,117]. By activation of 5-HT 3 receptors, instead, 5-HT stimulates the release of either glutamate [7,57,185] or GABA [90,96,179].…”

Section: Modes Of Interactionmentioning

confidence: 99%

“…In interneurons from stratum lacunosum-molecolare of the CA1 region, the amplitude of a T-type low threshold voltage-dependent Ca 2+ current, which is responsible for rhythmic oscillations of membrane potential, is enhanced by 5-HT and reduced by a GABA B agonists [54]. Concerning the role of different subtypes of 5- References: [9,79] HT receptors, it has been shown that GABA release from CA1 interneurons is inhibited by 5-HT 1A receptors [90,163] and enhanced by 5-HT 2 [166] and 5-HT 3 receptors [90,121,157,179]. An important issue is that a very large heterogeneity exists among hippocampal interneurons [148]: as a matter of fact, as many as 16 different types have been characterized based on their location and morphology; besides, hippocampal interneurons also differ with respect to colocalization of GABA with various peptides, expression of calcium binding proteins, expression of membrane ion channels, discharge patterns and responsiveness to neurotransmitters.…”

Section: Modes Of Interactionmentioning

confidence: 99%

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Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Ciranna

2006

268

170

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Abstract:The neurotransmitter serotonin (5-HT), widely distributed in the central nervous system (CNS), is involved in a large variety of physiological functions. In several brain regions 5-HT is diffusely released by volume transmission and behaves as a neuromodulator rather than as a "classical" neurotransmitter. In some cases 5-HT is co-localized in the same nerve terminal with other neurotransmitters and reciprocal interactions take place. This review will focus on the modulatory action of 5-HT on the effects of glutamate and -amino-butyric acid (GABA), which are the principal neurotransmitters mediating respectively excitatory and inhibitory signals in the CNS. Examples of interaction at preand/or post-synaptic levels will be illustrated, as well as the receptors involved and their mechanisms of action. Finally, the physiological meaning of neuromodulatory effects of 5-HT will be briefly discussed with respect to pathologies deriving from malfunctioning of serotonin system.

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Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats

Rex

Fink

2006

J. Neurosci. Res.

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Systemic administration of the 5-HT1A receptor agonist 8-OH-DPAT modifies 5-HT neuronal transmission via stimulation of presynaptic and postsynaptic receptors. Compared to the effects of presynaptic receptor stimulation, there are less data on the effects of postsynaptic 5-HT1A receptors and the net effects of a stimulation of pre- and postsynaptic 5-HT1A receptors available. We measured the neuronal activity in the rat hippocampus after systemic treatment with 8-OH-DPAT in doses (30-300 microg/kg) known to reduce 5-HT release and anxiety-like behavior in rodents. Neuronal activity was assessed by laser-induced fluorescence spectroscopy determining changes in nicotinamide adenine dinucleotide (NADH) fluorescence in the ventral hippocampus of anaesthetized rats in vivo. NADH, a co-substrate for energy transfer in the respiratory chain, mirrors mitochondrial activity. Increased NADH fluorescence signals lower consumption of NADH caused by neuronal inhibition. 8-OH-DPAT in a dose of 300 microg/kg, but not 100 microg/kg and 30 microg/kg, increased NADH fluorescence by maximal +27 +/- 3.5%, suggesting a decreased neuronal activity in the ventral hippocampus. The selective 5-HT1A antagonist WAY-100635 (3 mg/kg) prevented the increased NADH fluorescence after 8-OH-DPAT, but had no own effect. The results show that systemic administration of the 5-HT1A agonist 8-OH-DPAT dose-dependently affects neuronal activity in the ventral hippocampus. The dose of 300 microg/kg seemingly activates presynaptic and postsynaptic receptors with dominating inhibitory postsynaptic effects.

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A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons

Cited by 70 publications

References 27 publications

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

Serotonin as a Modulator of Glutamate- and GABA-Mediated Neurotransmission: Implications in Physiological Functions and in Pathology

Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats

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