A dissolving and glucose-responsive insulin-releasing microneedle patch for type 1 diabetes therapy

Zhang, Yujie; Wu, Mingxin; Tan, Di; Liu, Quan; Xia, Re; Chen, Min; Liu, Yuangang; Xue, Longjian; Lei, Yifeng

doi:10.1039/d0tb02133d

Cited by 52 publications

(45 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complex and well-defined dendritic structure was transformed into a porous construction after packaging with the Nafion ionomer (a biocompatible ionomer). Furthermore, Zhang et al [254] proposed a patch system, which comprised dissolving and insulin-releasing MN to respond to blood glucose levels. The system was designed as minimally invasive insulin therapy for type 1 diabetes mellitus patients.…”

Section: Glucose Sensorsmentioning

confidence: 99%

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

et al. 2021

View full text Add to dashboard Cite

Real-time “on-body” monitoring of human physiological signals through wearable systems developed on flexible substrates (e-skin) is the next target in human health control and prevention, while an alternative to bulky diagnostic devices routinely used in clinics. The present work summarizes the recent trends in the development of e-skin systems. Firstly, we revised the material development for e-skin systems. Secondly, aspects related to fabrication techniques were presented. Next, the main applications of e-skin systems in monitoring, such as temperature, pulse, and other bio-electric signals related to health status, were analyzed. Finally, aspects regarding the power supply and signal processing were discussed. The special features of e-skin as identified contribute clearly to the developing potential as in situ diagnostic tool for further implementation in clinical practice at patient personal levels.

show abstract

Section: Glucose Sensorsmentioning

confidence: 99%

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Also, to begin large-scale production of microneedles and minimize costs, the fabricated approach should be streamlined. Finally, in order to verify that microneedles can effectively function in a physiological setting, additional clinical trials must be considered [ 47 , 48 , 49 , 50 , 51 ].…”

Section: Microneedlementioning

confidence: 99%

Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles

et al. 2021

View full text Add to dashboard Cite

Insulin is used for the treatment of diabetes mellitus, which is characterized by hyperglycemia. Subcutaneous injections are the standard mode of delivery for insulin therapy; however, this procedure is very often invasive, which hinders patient compliance, particularly for individuals requiring insulin doses four times a day. Furthermore, cases have been reported of sudden hypoglycemia occurrences following multidose insulin injections. Such an invasive and intensive approach motivates the quest for alternative, more user-friendly insulin administration approaches. For example, transdermal delivery has numerous advantages, such as prolonged drug release, low variability in the drug plasma level, and improved patient compliance. In this paper, the authors summarize different approaches used in transdermal insulin delivery, including microneedles, chemical permeation enhancers, sonophoresis, patches, electroporation, iontophoresis, vesicular formulations, microemulsions, nanoparticles, and microdermabrasion. Transdermal systems for insulin delivery are still being widely researched. The conclusions presented in this paper are extracted from the literature, notably, that the transdermal route could effectively and reliably deliver insulin into the circulatory system. Consistent progress in this area will ensure that some of the aforementioned transdermal insulin delivery systems will be introduced in clinical practice and commercially available in the near future.

show abstract

“…Overall, the results showed in Figure 2D suggest greater investment in diseases that affect the immune system, prioritizing transcutaneous immunization and the management of psoriasis [40][41][42], superficial tumors [32][33][34][35][36]43], and diseases that affect the lymphatic system owing to its proximity to the systemic circulation, such as filariasis [22,44,45]. Above all, diabetes mellitus, which requires constant insulin administrations, was prioritized [20,46,47].…”

Section: Selection and General Characteristics Of Sources Of Evidencementioning

confidence: 99%

“…Moreover, one study evaluated the mechanical properties using atomic force microscopy to obtain the force-displacement curves. In this case, a 10 mm sphere of SiO 2 probe was applied with a 1 mN force at 500 nm/s [46].…”

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

“…Some studies explored pH values representative of blood pH (pH 7.4) and skin pH (pH 5.5). Similar to the dissolution assay, one study simulated hyperglycemic conditions in order to check whether the developed system was sensitive to different glucose concentrations [46]. However, temperature also ranged from 32 to 37 • C, representing normal skin surface temperature and internal temperature.…”

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

See 1 more Smart Citation

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

2021

View full text Add to dashboard Cite

The largest organ of the body provides the main challenge for the transdermal delivery of lipophilic or high molecular weight drugs. To cross the main barrier of the skin, the stratum corneum, many techniques have been developed and improved. In the last 20 years, the association of microneedles with nanostructured systems has gained prominence for its versatility and for enabling targeted drug delivery. Currently, the combination of these mechanisms is pointed to as an emerging technology; however, some gaps need to be answered to transcend the development of these devices from the laboratory scale to the pharmaceutical market. It is known that the lack of regulatory guidelines for quality control is a hindrance to market conquest. In this context, this study undertakes a scoping review of original papers concerning methods applied to evaluate both the quality and drug/protein delivery of dissolving and hydrogel-forming microneedles developed in association with nanostructured systems.

show abstract

A dissolving and glucose-responsive insulin-releasing microneedle patch for type 1 diabetes therapy

Abstract: Diabetes and its complications become crucial public health challenges worldwide. In this study, we aim to develop a dissolving and glucose responsive insulin releasing microneedle (MN) patch system, for minimally...

Cited by 52 publications

References 46 publications

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

Contact Info

Product

Resources

About