A Dissociation Between Anterograde and Retrograde Amnesia After Treatment With Electroconvulsive Therapy

O’Connor, Margaret; Lebowitz, Brian K.; Ly, Jenny; Panizzon, Matthew S.; Elkin-Frankston, Seth; Dey, Sangeeta; Bloomingdale, Kerry; Thall, Mark; Pearlman, Chester

doi:10.1097/yct.0b013e318158792f

Cited by 19 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we observed no retrograde amnesia. While the prevalence, severity, and duration of retrograde amnesia remains unknown, recent investigations have consistently reported the presence of this memory impairment post‐ECT . In regards to immediate post‐MST effects, the initial four patients awoke from the anesthetic fully oriented in a manner notably different from what is typically seen post‐ECT.…”

Section: Discussionmentioning

confidence: 96%

Pilot Study of the Clinical and Cognitive Effects of High-Frequency Magnetic Seizure Therapy in Major Depressive Disorder

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Pilot Study of the Clinical and Cognitive Effects of High-Frequency Magnetic Seizure Therapy in Major Depressive Disorder

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Research has suggested that the confusion after each ECT treatment and the anterograde amnesia are time-limited (11-15), but retrograde amnesia has been found to persist up to and past 6-months in some cases (11-15). Patient-specific factors including greater age (16), lower education level, and lower premorbid intelligence (17) may increase the level of cognitive impairment associated with ECT.…”

Section: Electroconvulsive Therapymentioning

confidence: 99%

Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: A review

2011

View full text Add to dashboard Cite

Electroconvulsive therapy (ECT) and ablative neurosurgical procedures are established interventions for treatment-resistant depression (TRD), but their use may be limited in part by neuropsychological adverse effects. Additional neuromodulation strategies are being developed that aim to match or exceed the efficacy of ECT/ablative surgery with a better neurocognitive side effect profile. In this review, we briefly discuss the neurocognitive effects of ECT and ablative neurosurgical procedures, then synthesize the available neurocognitive information for emerging neuromodulation therapies including repetitive transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, vagus nerve stimulation, and deep brain stimulation. The available evidence suggests these procedures may be more cognitively benign relative to ECT or ablative neurosurgical procedures, though further research is clearly needed to fully evaluate the neurocognitive effects, both positive and negative, of these novel neuromodulation interventions.

show abstract

“…Using this technique, O’Connor et al were able to show that retrograde memory, but not anterograde memory, was somewhat impaired. 33 The study was not designed to evaluate long-term personal memory or unilateral/bilateral differences. It would have been interesting if the researchers had included a second control sample of depressed patients who were receiving medication instead of ECT.…”

Section: Commentarymentioning

confidence: 99%

Major Depressive Disorder with Psychotic Features May Lead to Misdiagnosis of Dementia

Wagner

McClintock

Rosenquist

et al. 2011

Journal of Psychiatric Practice

View full text Add to dashboard Cite

Major depressive disorder (MDD) with psychotic features is relatively frequent among patients with greater depressive symptom severity and is associated with a poorer course of illness and more functional impairment than MDD without psychotic features. Multiple studies have found that patients with psychotic mood disorders demonstrate significantly poorer cognitive performance in a variety of areas than those with nonpsychotic mood disorders. The Mini Mental State Examination (MMSE) and the Dementia Rating Scale (DRS-2) are widely used to measure cognitive functions in research on MDD with psychotic features. Established total raw score cut-offs of 24 on the MMSE and of 137 on the DRS-2 in published manuals suggest possible global cognitive impairment and dementia, respectively. Limited research is available on these suggested cut-offs for patients with MDD with psychotic features. We document the therapeutic benefit of electroconvulsive therapy (ECT), which is usually associated with short-term cognitive impairment, in a 68-year-old woman with psychotic depression whose MMSE and DRS-2 scores initially suggested possible global cognitive impairment and dementia. Over the course of four ECT treatments, this patient’s MMSE scores progressively increased. After the second ECT treatment, the patient no longer met criteria for global cognitive impairment. With each treatment, depression severity, measured by the 24-item Hamilton Rating Scale for Depression, improved sequentially. Thus, the suggested cut-off scores for the MMSE or DRS-2 in patients with MDD with psychotic features may in some cases produce false-positive indications of dementia.

show abstract

A Dissociation Between Anterograde and Retrograde Amnesia After Treatment With Electroconvulsive Therapy

Abstract: Results of the study suggest that a clinical course of ECT is associated with isolated impairment for information learned before treatment (ie, retrograde memory), whereas there was no effect of ECT on posttreatment learning abilities (ie, anterograde memory).

Cited by 19 publications

References 21 publications

Pilot Study of the Clinical and Cognitive Effects of High-Frequency Magnetic Seizure Therapy in Major Depressive Disorder

Pilot Study of the Clinical and Cognitive Effects of High-Frequency Magnetic Seizure Therapy in Major Depressive Disorder

Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: A review

Major Depressive Disorder with Psychotic Features May Lead to Misdiagnosis of Dementia

Contact Info

Product

Resources

About