A disposable electrochemical aptasensor using single-stranded DNA–methylene blue complex as signal-amplification platform for sensitive sensing of bisphenol A

Z, Yu; Luan, Yanan; Li, Haiyu; Wang, Wan; Wang, Xiayan; Zhang, Qing

doi:10.1016/j.snb.2018.12.126

Cited by 57 publications

(21 citation statements)

References 33 publications

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“…This type of transducer shows excellent accuracy, repeatability, and resolution, but they can be easily influenced by temperature changes, resulting in a short shelf-life [ 66 ]. Electrochemical biosensors mainly utilize enzymes as the recognition part due to the specificity of enzymatic reactions [ 67 ]. One of the most commonly used biosensors employing the electrochemical transducer is glucometer.…”

Section: Classification Of Biosensorsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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Natural products (NPs) are a valuable source in the food, pharmaceutical, agricultural, environmental, and many other industrial sectors. Their beneficial properties along with their potential toxicities make the detection, determination or quantification of NPs essential for their application. The advanced instrumental methods require time-consuming sample preparation and analysis. In contrast, biosensors allow rapid detection of NPs, especially in complex media, and are the preferred choice of detection when speed and high throughput are intended. Here, we review diverse biosensors reported for the detection of NPs. The emerging approaches for improving the efficiency of biosensors, such as microfluidics, nanotechnology, and magnetic beads, are also discussed. The simultaneous use of two detection techniques is suggested as a robust strategy for precise detection of a specific NP with structural complexity in complicated matrices. The parallel detection of a variety of NPs structures or biological activities in a mixture of extract in a single detection phase is among the anticipated future advancements in this field which can be achieved using multisystem biosensors applying multiple flow cells, sensing elements, and detection mechanisms on miniaturized folded chips.

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Section: Classification Of Biosensorsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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“…S4) can be separated into two peaks at the BEs of 132.9 and 133.9 eV, which are due to P 2p 3/2 and P 2p 1/2 , respectively. Apparently, the clear P 2p XPS signal is from the phosphate backbone of the N 58 aptamer [66].…”

Section: Basic Characterizations Of Nb 2 C-sh Qdsmentioning

confidence: 98%

Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detection

et al. 2021

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A novel label-free surface plasmon resonance (SPR) aptasensor has been constructed for the detection of N-gene of SARS-CoV-2 by using thiol-modified niobium carbide MXene quantum dots (Nb 2 C-SH QDs) as the bioplatform for anchoring N-genetargeted aptamer. In the presence of SARS-CoV-2 N-gene, the immobilized aptamer strands changed their conformation to specifically bind with N-gene. It thus increased the contact area or enlarged the distance between aptamer and the SPR chip, resulting in a change of the SPR signal irradiated by the laser (He-Ne) with the wavelength (λ) of 633 nm. Nb 2 C QDs were derived from Nb 2 C MXene nanosheets via a solvothermal method, followed by functionalization with octadecanethiol through a self-assembling method. Subsequently, the gold chip for SPR measurements was modified with Nb 2 C-SH QDs via covalent binding of the Au-S bond also by self-assembling interaction. Nb 2 C-SH QDs not only resulted in high bioaffinity toward aptamer but also enhanced the SPR response. Thus, the Nb 2 C-SH QD-based SPR aptasensor had low limit of detection (LOD) of 4.9 pg mL −1 toward N-gene within the concentration range 0.05 to 100 ng mL −1 . The sensor also showed excellent selectivity in the presence of various respiratory viruses and proteins in human serum and high stability. Moreover, the Nb 2 C-SH QD-based SPR aptasensor displayed a vast practical application for the qualitative analysis of N-gene from different samples, including seawater, seafood, and human serum. Thus, this work can provide a deep insight into the construction of the aptasensor for detecting SARS-CoV-2 in complex environments.

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“…These methods can offer good accuracy and sensitivity, however they have some drawbacks, such as high-cost equipment, time consuming operation and unsuitability for onsite analysis [11,12], thus restricting their application. On contrary, electrochemical sensors have been extensively used as an alternative solution for detecting trace levels of BPA due to their inherent advantages such as low cost, short analysis time, portability and excellent sensitivity [13]. Direct monitor BPA using an electrochemical sensor with a bare electrode has a poor response due to fouling and sluggish electron transfer kinetics [14].…”

Section: Introductionmentioning

confidence: 99%

Novel Sensor Based on Nanocarbon Transducer Functionalized by Iron (III) Porphyrin for the Impedimetric Detection of Bisphenol A

Hsine¹,

Mlika²

2022

Bisphenols

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In this chapter, an impedimetric response of iron (III) porphyrin (Fe(III)TMPP) functionalized on gold transducer towards the detection of three phenolic compounds entitled bisphenol A (BPA), 2,2′-biphenol and catechol has been studied. The bisphenol A that has revealed the best affinity with Fe(III)TMPP membrane has been chosen as the target analyte. For improved sensitivity of Au/Fe(III)TMPP sensor towards BPA, a facile and efficient Au/RGO nanocarbon transducer based on reduced graphene oxide (RGO) has been prepared and used to support Fe(III)TMPP membrane. The obtained Au/RGO/Fe(III)TMPP structure was characterized by UV–visible (UV–vis) and electrochemical impedance spectroscopy (EIS) measurements, then applied as electrochemical platform for BPA detection. It has been discovered that the Au/RGO nanocarbon transducer has an amplified electron transfer kinetic compared to unmodified Au transducer. The Au/RGO/Fe(III)TMPP structure has showed a better affinity towards BPA with a doubled sensitivity compared to that obtained with Au/Fe(III)TMPP electrode. We demonstrated that the Au/RGO nanocarbon transducer not only enhances the electron transfer ability but also serves as a good template for the attachment of Fe(III)TMPP throughπ-π interaction. This study reveals new high-potential of nanocarbon transducer based on RGO for the conception of electrochemical sensors with high sensitivity and short response time.

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A disposable electrochemical aptasensor using single-stranded DNA–methylene blue complex as signal-amplification platform for sensitive sensing of bisphenol A

Cited by 57 publications

References 33 publications

Emerging biosensors in detection of natural products

Emerging biosensors in detection of natural products

Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detection

Novel Sensor Based on Nanocarbon Transducer Functionalized by Iron (III) Porphyrin for the Impedimetric Detection of Bisphenol A

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