A disposable amperometric dual-sensor for the detection of hemoglobin and glycated hemoglobin in a finger prick blood sample

Moon, Jong‐Min; Kim, Dong-Min; Kim, Moo Hyun; Han, Jin‐Yeong; Jung, Dong Keun; Shim, Yoon‐Bo

doi:10.1016/j.bios.2016.12.038

Cited by 72 publications

(24 citation statements)

References 34 publications

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“…Shumyantseva et al [143,144] achieved this in a myoglobin sensing platform through the inclusion of multi-walled carbon nanotubes (MWCNT), giving a detection limit of 9 ng mL −1 . MWCNTs can also be mixed with conducting polymers to form composites that allow for the immobilization of sensing components to produce stable and sensitive probes [145]. The increased surface area of the transducer allows for a larger number of imprints and therefore an increased signal in the absence of the template.…”

Section: Biosensing Platforms Incorporating Electrosynthesized Molmentioning

confidence: 99%

Recent Advances in Electrosynthesized Molecularly Imprinted Polymer Sensing Platforms for Bioanalyte Detection

Crapnell

Hudson

Foster

et al. 2019

Sensors

182

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The accurate detection of biological materials has remained at the forefront of scientific research for decades. This includes the detection of molecules, proteins, and bacteria. Biomimetic sensors look to replicate the sensitive and selective mechanisms that are found in biological systems and incorporate these properties into functional sensing platforms. Molecularly imprinted polymers (MIPs) are synthetic receptors that can form high affinity binding sites complementary to the specific analyte of interest. They utilise the shape, size, and functionality to produce sensitive and selective recognition of target analytes. One route of synthesizing MIPs is through electropolymerization, utilising predominantly constant potential methods or cyclic voltammetry. This methodology allows for the formation of a polymer directly onto the surface of a transducer. The thickness, morphology, and topography of the films can be manipulated specifically for each template. Recently, numerous reviews have been published in the production and sensing applications of MIPs; however, there are few reports on the use of electrosynthesized MIPs (eMIPs). The number of publications and citations utilising eMIPs is increasing each year, with a review produced on the topic in 2012. This review will primarily focus on advancements from 2012 in the use of eMIPs in sensing platforms for the detection of biologically relevant materials, including the development of increased polymer layer dimensions for whole bacteria detection and the use of mixed monomer compositions to increase selectivity toward analytes.

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Section: Biosensing Platforms Incorporating Electrosynthesized Molmentioning

confidence: 99%

Recent Advances in Electrosynthesized Molecularly Imprinted Polymer Sensing Platforms for Bioanalyte Detection

Crapnell

Hudson

Foster

et al. 2019

Sensors

182

View full text Add to dashboard Cite

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“…The C 1s peak at 284.5 eV is attributed to C‐C and C‐H, and the peak at 284.1 eV reveals the contribution to C=C of the aromatics in EP‐5, which means that the graphite structure may be formed by dehydration during combustion . The peak at 285.1 eV is attributed to C‐O‐C and C‐OP, whereas the peak at 290.1 eV corresponds to C‐P . The O 1s peak centered at 532.4 eV is attributed to C‐C/C‐H/C‐O‐P/P‐O‐P .…”

Section: Resultsmentioning

confidence: 99%

“…whereas the peak at 290.1 eV corresponds to C-P. 45,46 The O 1s peak centered at 532.4 eV is attributed to C-C/C-H/C-O-P/P-O-P. 47,48 Meanwhile, the peak of 531.5 eV is attributed to C=O/P=O and the peak of 533.3 eV is attributed to PhOCOOPh. 49,50 The N 1s peaks at 398.4 and 399.6 eV can be attributed to C-N and C=N.…”

Section: Flame-retardant Mechanism Of Cured Epoxy Resinsmentioning

confidence: 99%

Highly efficient multielement flame retardant for multifunctional epoxy resin with satisfactory thermal, flame‐retardant, and mechanical properties

Chen

Lin

et al. 2019

Polymers for Advanced Techs

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Multifunctional epoxy resins with excellent, thermal, flame‐retardant, and mechanical properties are extremely important for various applications. To solve this challenging problem, a novel highly efficient multielement flame retardant (PMSBA) is synthesized and the flame‐retardant and mechanical properties of modified epoxy resins are greatly enhanced without significantly altering their and thermal properties by applying the as‐synthesized PMSBA. The limiting oxygen index value reaches up to 29.6% and could pass the V‐0 rating in the UL‐94 test with even low P content (0.13%). Furthermore, cone calorimetry results demonstrate that 30.3% reduction in the peak heat release rate for the sample with 10.0 wt% PMSBA is achieved. X‐ray photoelectron spectroscopy and scanning electron microscopy indicate that Si‐C, Si‐N, and phosphoric acid derivative can be transformed into a multihole and intumescent char layer as an effective barrier, preserving the epoxy resin structure from fire. More importantly, mechanical properties such as impact strength, tensile strength, and flexural strength are also increased by 63.86%, 33.54%, and 15.65%, respectively, which show the incorporation of PMSBA do not deteriorate the mechanical properties of modified epoxy resins. All the results show that PMSBA is a promising strategy for epoxy resin with satisfactory, thermal, flame‐retardant, and mechanical properties.

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“…Moon and coworkers developed a disposable microfluidic amperometric dual-sensor for the detection of HbA1c and total Hb separately [ 74 ]. The concentration of total Hb was measured by the cathodic currents of total Hb catalyzed by a TBO/pTTBA@MWCNT-modified working electrode.…”

Section: Analysis Of Samples From Human Bloodmentioning

confidence: 99%

Current Status of HbA1c Biosensors

Hua

2017

Sensors

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Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α–amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements.

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A disposable amperometric dual-sensor for the detection of hemoglobin and glycated hemoglobin in a finger prick blood sample

Cited by 72 publications

References 34 publications

Recent Advances in Electrosynthesized Molecularly Imprinted Polymer Sensing Platforms for Bioanalyte Detection

Recent Advances in Electrosynthesized Molecularly Imprinted Polymer Sensing Platforms for Bioanalyte Detection

Highly efficient multielement flame retardant for multifunctional epoxy resin with satisfactory thermal, flame‐retardant, and mechanical properties

Current Status of HbA1c Biosensors

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