A disintegrin and metalloproteinase 33 (ADAM33) gene polymorphism association with asthma in Egyptian children

El-Falaki, Mona Mostafa; Wilson, Manal; Ezzat, Ghada M; Mokhtar, Doha A.; Baz, Mohamed S. El; Hamed, Dina H.

doi:10.1016/j.ejmhg.2012.08.005

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…These findings are in agreement with a study conducted in a population of the Caribbean coast of Colombia that showed a significant association of the (GG) genotype of the T1 polymorphism with high total IgE levels ( p = 0.04) and the (AA) genotype of T2 with high total IgE ( p = 0.02) and high levels of IgE against Dermatophagoides pteronyssinus ( p = 0.03) [ 20 ]. A similar result was also observed in a study carried out on Egyptian children that reported significantly higher IgE levels in patients with T1 (GG) genotype [ 21 ]. In asthmatic adults, we identified a significant association of T1 and T2 with IgE levels in both dominant ( p = 0.024 and 0.0175, respectively) and recessive models ( p = 0.0407 and 0.015, respectively).…”

Section: Discussionsupporting

confidence: 87%

“…Studies conducted in China [ 23 ] and the U.S. [ 24 ] also found a significant association between the ADAM33 V4 allele and asthma ( p = 0.0001 and p = 0.032, respectively). In correlation with these results, a study in Egypt [ 21 ] which examined T1, T2, and V4 alleles showed no association between V4 and IgE levels. Interestingly, the V4 polymorphism showed a positive correlation, with passive smoking being a precipitating factor and showing borderline significance with absolute eosinophilia.…”

Section: Discussionmentioning

confidence: 74%

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The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients

Zihlif

Imraish

Al‐Rawashdeh

et al. 2021

JPM

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Total serum immunoglobulin E (IgE) is elevated in multiple allergic diseases and is considered a good predictor of atopy. Several studies have been performed on the association of IgE levels with the polymorphism of the ADAM33 gene in asthmatic patients. The aim of this study was to determine whether there is an association between IgE levels and the genetic polymorphisms of the ADAM33 gene (T1, T2, T + 1, V4, S1, S2, and Q-1) in both healthy and asthmatic patients among Jordanians. The clinical data were collected for this case–control study from 267 asthmatic patients and 225 control subjects. Seven genetic polymorphisms (T1, T2, T + 1, V4, S1, S2, and Q-1) of the gene ADAM33 were analyzed using the polymerase chain reaction/restriction fragment length polymorphism method. The minor alleles (G) of T1, (A) of T2, T + 1, and (G) of V4 polymorphisms were associated with a significant increase in total serum IgE levels in adults but not children. The V4 genetic polymorphism, however, showed a significant association with IgE levels in both adults and children. The S1 polymorphism was significantly associated with the codominant module only in the adults. The S2 polymorphism showed a significant association (p-value < 0.05) in both codominant and recessive models. However, in the dominant model for both pediatric control and asthmatic patients, the association between the IgE and S2 polymorphism was insignificant (p-value = 0.7271 and 0.5259, respectively). This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 74%

The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients

Zihlif

Imraish

Al‐Rawashdeh

et al. 2021

JPM

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“…The same study also predicted a low LD between the SNP variants in the Li population. These findings of a low LD for the target SNPs were also reported in others populations, including Mongolians and Egyptians 28,29…”

Section: Discussionsupporting

confidence: 84%

Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Ghani

Sabar

Bano

et al. 2019

SMJ

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Objectives: To investigate the relationship of 3 single nucleotide polymorphism (SNP) variants of ADAM33 with asthma susceptibility in patients from Northern and Central Punjab, Punjab, Pakistan. Methods: In this case-control study, healthy and asthmatic participants were recruited between 2015 and 2017. The SNPs of ADAM33 gene, rs2280089, rs2280090, and rs2280091 were analyzed in 296 asthma patients and 343 healthy controls, as well as linkage disequilibrium and haplotype analysis. Results: The non-significant differences were observed in allele and genotype frequencies of the SNPs in asthmatic and healthy persons even after population stratification based on age, caste, gender, family history, and environment. Although these SNPs were non-significant for disease susceptibility among children and adults, a fixed unique pattern of inheritance was nevertheless observed for the studied SNPs. Linkage disequilibrium analysis presented a very strong linkage between the SNP variants to predict their co-inheritance in study population. However, none of the haplotypes were found to be associated with asthma disease development. Conclusion: The studied SNPs of ADAM33 appeared to be non-significant for asthma susceptibility in Northern and Central Punjabi population. The fixed allele combination inheritance pattern was a unique observation contrary to findings in other global populations.

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“…23 Recently, in another Egyptian study done on 32 CF patients, 61% were ΔF508 mutation positive, 22.2% were homozygous, and 38.8% were heterozygous. 24 Analysis of frequency of the three studied mutations in our cases revealed that the most common allele was ΔF508; 60 alleles in 56 individuals followed by W1282X in 25 and G542X in 12 individuals. Probands with two alleles were genotyped either homozygous ΔF508/ΔF508 (4 cases), compound heterozygous ΔF508/W1282X, or ΔF508/G542X (in 20 and 12 cases, respectively).…”

Section: Discussionmentioning

confidence: 64%

Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma

et al. 2020

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Cystic fibrosis (CF) is panethnic autosomal recessive disease that affects the exocrine glands of pancreas, lungs, and intestine. It is often misdiagnosed in developing countries as difficult-to-treat asthma. We enrolled 150 Egyptian families with one or more probands who were complaining of difficult-to-treat asthma, and 112 cases were studied extensively through history taking including pedigree construction and clinical examination. In addition, spirometry and computed tomography of the chest were done in selected cases. All cases were subjected to quantitative sweat chloride test and molecular screening for the three most common mutations of cystic fibrosis transconductance regulator (CFTR) gene (ΔF508, G542X, W1282X) using amplification refractory mutation system (ARMS) technique. Probands of difficult-to-treat asthma comprised 66 males and 46 females; their age range was 1 to 14 years. Sixty-one probands (54.5%) were carriers of one or more of the studied mutations (36 cases and 25 carriers). Six carriers of single mutations had mild respiratory symptoms and negative sweat test. The most common allele was ΔF508, 60 alleles in 56 individuals (4 were homozygous ΔF508/ΔF508) followed by W1282X in 25 individuals and G542X in 12 individuals. Allele W1282X had an increased risk of recurrent chest infection and bronchiectasis. Moreover, cases with two mutations had more severe symptoms compared with those with a single mutation. CFTR mutations and CF-related syndromes are not rare as thought in Egypt, especially among the high-risk difficult-to-treat asthma. The readily available ARMS technique is recommended for ΔF508 and/or W1282X screening on priority basis among these children.

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A disintegrin and metalloproteinase 33 (ADAM33) gene polymorphism association with asthma in Egyptian children

Cited by 7 publications

References 28 publications

The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients

The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients

Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan

Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma

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