A direct visuosensory cortical connectivity of the human limbic system. Dissecting the trajectory of the parieto-occipito-hypothalamic tract in the human brain using diffusion weighted tractography

Kamali, Arash; Sherbaf, Farzaneh Ghazi; Rahmani, Farzaneh; Khayat-Khoei, Mahsa; Aein, Azin; Gandhi, Anusha; Shah, Ekta G.; Sair, Haris I.; Riascos, Roy F.; Esquenazi, Yoshua; Zhu, Jay Jiguang; Keser, Zafer; Hasan, Khader M.

doi:10.1016/j.neulet.2020.134955

Cited by 9 publications

(13 citation statements)

References 20 publications

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“…The parieto-occipito-hypothalamic tract seems to allow for visuosensory information to be carried from the parietal and occipital cortices to the limbic system, especially the HT and the bed nucleus of the stria terminalis. This finding stresses the point that many limbic functions, such as hunger, fear or circadian rhythm rely on visuo-sensory information ( 78 ).…”

Section: Structural Connectivity Of Hypothalamussupporting

confidence: 68%

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

et al. 2022

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Hypothalamus (HT), this small structure often perceived through the prism of neuroimaging as morphologically and functionally homogeneous, plays a key role in the primitive act of feeding. The current paper aims at reviewing the contribution of magnetic resonance imaging (MRI) in the study of the role of the HT in food intake regulation. It focuses on the different MRI techniques that have been used to describe structurally and functionally the Human HT. The latest advances in HT parcellation as well as perspectives in this field are presented. The value of MRI in the study of eating disorders such as anorexia nervosa (AN) and obesity are also highlighted.

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Section: Structural Connectivity Of Hypothalamussupporting

confidence: 68%

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

et al. 2022

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“…It has been suggested that neural mechanisms associated to visual manifestations commonly described by patients with migraine during and between attacks, like light hypersensitivity, can involve a complex brain network including retinal afferents, trigeminal nuclei, hypothalamus, thalamus, and visual processing cortical areas (1,29). Recent studies demonstrated direct connections of the hypothalamus with visual cortical areas, with possible implications in visuospatial processing, regulating the circadian rhythm and encoding the salience of multisensory information (9,30). Both the hypothalamus and visual cortex show an abnormal activation across all phases of the migraine attack (3,4,27).…”

Section: Discussionmentioning

confidence: 99%

“…Image acquisition: Using a 3.0 Tesla Intera scanner (Philips Medical Systems, Best, The Netherlands), the following brain sequences were obtained from all participants at baseline and follow-up: a) RS fMRI scans (T2*-weighted echo planar imaging sequence with 200 sets of 30 . During the RS fMRI acquisition, participants were instructed to stay awake with their eyes closed.…”

Section: Methodsmentioning

confidence: 99%

Clinical correlates of hypothalamic functional changes in migraine patients

et al. 2021

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Objective To elucidate the hypothalamic involvement in episodic migraine and investigate the association between hypothalamic resting state functional connectivity changes and migraine patients’ clinical characteristics and disease progression over the years. Methods Ninety-one patients with episodic migraine and 73 controls underwent interictal resting state functional magnetic resonance imaging. Twenty-three patients and controls were re-examined after a median of 4.5 years. Hypothalamic resting state functional connectivity changes were investigated using a seed-based correlation approach. Results At baseline, a decreased functional interaction between the hypothalamus and the parahippocampus, cerebellum, temporal, lingual and orbitofrontal gyrus was found in migraine patients versus controls. Increased resting state functional connectivity between the hypothalamus and bilateral orbitofrontal gyrus was demonstrated in migraine patients at follow-up versus baseline. Migraine patients also experienced decreased right hypothalamic resting state functional connectivity with ipsilateral lingual gyrus. A higher migraine attack frequency was associated with decreased hypothalamic-lingual gyrus resting state functional connectivity at baseline, while greater headache impact at follow-up correlated with decreased hypothalamic-orbitofrontal gyrus resting state functional connectivity at baseline. At follow-up, a lower frequency of migraine attacks was associated with higher hypothalamic-orbitofrontal gyrus resting state functional connectivity. Conclusions During the interictal phase, the hypothalamus modulates the activity of pain and visual processing areas in episodic migraine patients. The hypothalamic-cortical interplay changes dynamically over time according to patients’ clinical features.

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“…Tigges et al reported projections from the LH to the parietal and occipital cortices in chimpanzee modes. 30 In humans, Kamali et al also demonstrated the long direct connectivity from hypothalamus to the parietal and occipital lobes by diffusion-weighted imaging, 31 which may carry the visuosensory-related information directly from the visuosensory cortices to the limbic system. Our results may be strongly associated with this increased transmission of visuosensory information in sALS.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Minor C Allele of CNTN4 rs2619566 on Medial Hypothalamic Connectivity in Early-Stage Patients of Chinese Han Ancestry with Sporadic Amyotrophic Lateral Sclerosis

Wang¹,

He²,

Zhu³

et al. 2022

NDT

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Objective Clinical symptoms such as major defects in energy metabolism may involve the hypothalamus in amyotrophic lateral sclerosis (ALS) patients. Our recent study discovered that the single-nucleotide polymorphisms (SNPs) of rs2619566, rs79609816 and rs10260404 are associated with sporadic ALS (sALS). Thus, this study aims to investigate the hypothalamic functional reorganization and its association with the above polymorphisms risk alleles in sALS patients of Chinese Han ancestry. Methods Forty-four sALS patients (28 males/16 females) and 40 healthy subjects (HS; 28 males/12 females) underwent resting-state functional MRI, genotyping and clinical assessments. A two-sample t test ( P < 0.01, GRF correction at P < 0.05) was performed to compare hypothalamic connectivity for group-level analysis in disease diagnosis and genotype, and then the genotype-diagnosis interaction effect was assessed. Finally, Spearman correlation analyses were performed to assess the relationship between the altered functional connectivity and their clinical characteristics. Results The sALS patients showed a short disease duration (median = 12 months). Regarding the diagnosis effect, the sALS patients showed widespread hypothalamic hyperconnectivity with the left superior temporal gyrus/middle temporal gyrus, right inferior frontal gyrus, and left precuneus/posterior cingulate gyrus. For the genotype effect of SNPs, hyperconnectivity was observed in only the medial hypothalamus when the sALS patients harboring the minor C allele of rs2619566 in contactin-4 ( CNTN4 ), while the sALS patients with the TT allele showed a hyperconnectivity network in the right lateral hypothalamus. This connectivity pattern was not observed in other SNPs. No significant genotype-diagnosis interaction was found. Moreover, altered functional connectivity was not significantly correlated with clinical characteristics ( P : 0.11–0.90). Conclusion These results demonstrated widespread hypothalamic hyperconnectivity in sALS. The risk allele C of the CNTN4 gene may therefore influence functional reorganization of the medial hypothalamus. The effects of the CNTN4 rs2619566 polymorphism may exist in the hypothalamic functional connectivity of patients with sALS.

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A direct visuosensory cortical connectivity of the human limbic system. Dissecting the trajectory of the parieto-occipito-hypothalamic tract in the human brain using diffusion weighted tractography

Cited by 9 publications

References 20 publications

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

Clinical correlates of hypothalamic functional changes in migraine patients

Effect of the Minor C Allele of CNTN4 rs2619566 on Medial Hypothalamic Connectivity in Early-Stage Patients of Chinese Han Ancestry with Sporadic Amyotrophic Lateral Sclerosis

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