“…While peptide antigen recognition forms the central dogma of classical T-cell–mediated adaptive immunity, the role of lipids as nonclassical antigens, presented by major histocompatibility complex class I–like molecules known as CD1, are emerging as new targets of protection and autoimmunity. CD1 mediated T-cell response to bacteria like Mycobacterium tuberculosis ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ), and self-lipid antigens mediate autoreactivity and autoimmune disease via lipid activation ( 15 , 16 , 17 , 18 , 19 , 20 ), lipid-independent binding ( 21 , 22 , 23 , 24 , 25 ), and lipid-blocking mechanisms ( 26 ).…”