A Direct Method for the Derivation of Thermodynamic Excess Functions from <i>TX</i> Phase Diagrams

Brouwer, N.; Oonk, H. A. J.

doi:10.1524/zpch.1979.117.117.055

Cited by 14 publications

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“…Taking into account the new liquidus points obtained by HPLC for the left-hand side of the phase diagram as well as those obtained by DSC for the right-hand side of the phase diagram (Table 1), a thermodynamic assessment of the diagram was carried out using the EXTXD method. 6 Thus, the liquidus curve was assessed by calculating the excess Gibbs energy in the liquid state using a Redlich-Kister third order polynomial and taking into account a total immiscibility in the solid state between the two substances. The best fit was obtained for G E,liq = x Â (1 À x)[100-1000 Â (1 À 2x)], where x stands for the molar fraction in acetaminophen.…”

Section: Resultsmentioning

confidence: 99%

Incidence of the melting-degradation process of vitamin C on the determination of the phase diagram with acetaminophen enhanced by high performance liquid chromatography tools

2015

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Section: Resultsmentioning

confidence: 99%

Incidence of the melting-degradation process of vitamin C on the determination of the phase diagram with acetaminophen enhanced by high performance liquid chromatography tools

2015

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“…The excess Gibbs energy of the liquid phase ( G excess liquid ) was then calculated at the eutectic point, using the EXTXD method . Consequently, the excess entropy was estimated from G excess liquid = H excess liquid − T e · S excess liquid (Table ), where T e is the eutectic temperature.…”

Section: Resultsmentioning

confidence: 99%

Lidocaine/l-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility

et al. 2010

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We present the synthesis, structure determination, and thermodynamic properties of a never reported cocrystal prepared with lidocaine and L-menthol. The temperature-composition phase diagram of the lidocaine/L-menthol binary system was achieved using differential scanning calorimetry and X-ray diffraction experiments. The present study demonstrates that the only way to perform a phase equilibrium survey of the lidocaine/L-menthol system is to prepare the binary mixtures from the cocrystal, an equimolar stoichiometric compound of L-menthol and lidocaine. We describe a process that is crucial to elaborate pharmaceutical agents that remain in their thermodynamical stable state throughout their preparation, manufacture, and storage for effective use.

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Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid

Corvis

Négrier

Espeau

2011

Journal of Pharmaceutical Sciences

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ABSTRACT:The aim of this study was to investigate the solid dispersion phase behavior of S-or RS-ibuprofen in stearic acid. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary mixtures. This indicates that no specific interactions exist between the chosen excipient and active pharmaceutical ingredient (API) that lead to eutectic systems. Furthermore, based on calorimetric and X-ray diffraction experiments, we have showed that upon cooling of the molten state, only stearic acid recrystallizes in the presence of S-ibuprofen, whereas a quaternary phase mixture is obtained for the racemic ibuprofen/stearic acid preparation. The solubility of stearic acid in S-ibuprofen liquid in all proportions was also determined. Overall, the results presented here offer an approach for the study of API/excipient interactions.

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A Direct Method for the Derivation of Thermodynamic Excess Functions from TX Phase Diagrams

Cited by 14 publications

References 0 publications

Incidence of the melting-degradation process of vitamin C on the determination of the phase diagram with acetaminophen enhanced by high performance liquid chromatography tools

Incidence of the melting-degradation process of vitamin C on the determination of the phase diagram with acetaminophen enhanced by high performance liquid chromatography tools

Lidocaine/l-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility

Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid

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