A direct mass spectrometry method for cannabinoid quantitation in urine and oral fluid utilizing reactive paper spray ionization

Abstract

A direct mass spectrometry method utilizing reactive paper spray ionization was developed for sensitive cannabinoid quantitation in biofluid matrices. The ca. 2-minute sample measurements used on-paper derivatization to significantly increase...

Simultaneous quantitation of urinary albumin and creatinine for rapid clinical albuminuria diagnostics using high-throughput paper spray mass spectrometry

“…32 Qualifier ions were used to confirm albumin and creatinine results across spiked and real urine samples using a qualifier-to-quantifier ion ratio threshold of ±20%. Typical PS-MS experiments [33][34][35][36] require only 1 min of analysis to achieve satisfactory results (e.g., creatinine and creatinine-d 3 in Fig. 3).…”

“…Typical PS-MS experiments 33–36 require only 1 min of analysis to achieve satisfactory results ( e.g. , creatinine and creatinine- d 3 in Fig.…”

Applications of ambient ionization mass spectrometry in 2022: An annual review

“…Similarly, Borden et al used a reactive PS-MS method for the detection of cannabinoids in urine and saliva. 39 An on-paper derivatization method was used to increase the sensitivity of the technique, resulting in a limit of detection (LOD) of 0.8 ng/m for THC in saliva and 1.3 ng/ml for carboxy-THC in urine, the primary metabolite of THC. Finally, Vejar-Vivar et al…”

Rapid fabrication of hydrophobic/hydrophilic patterns on paper substrates for paper spray mass spectrometry

“…extraction). 11,[53][54][55] These and other strategies will be a focus for improving sensitivity and LODs for our methods in the future.…”