A dimensional perspective on the genetics of obsessive-compulsive disorder

Strom, Nora; Soda, Takahiro; Mathews, Carol A.; Davis, Lea K.

doi:10.1038/s41398-021-01519-z

Cited by 21 publications

(13 citation statements)

References 143 publications

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“…The results of this thesis are in line with previous research which emphasize the heterogeneity of OCD (e.g., Shephard et al, 2021;Strom et al, 2021;. The presentation of affective symptoms differs between symptom dimensions, as shown in chapter 2 and 4.…”

Section: Discussionsupporting

confidence: 89%

Affecting OCD

Rickelt¹

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published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain 10 Chapter 1• The sensorimotor CSTC circuit (from the supplementary motor area to the posterior part of the putamen to the thalamus and back) has a significant role in habitual behavior.• The dorsal cognitive CSTC circuit (from the pre-supplementary motor area, dorsolateral and dorsomedial prefrontal cortex to the dorsal caudate nucleus to the thalamus and back) is related to working memory, planning and emotion regulation.• The ventral cognitive CSTC circuit (from the inferior frontal gyrus and ventrolateral prefrontal cortex to the ventral caudate nucleus to the thalamus and back) is associated with response inhibition.• The ventral motivational CSTC circuit (from the orbitofrontal cortex to the nucleus accumbens to the thalamus and back) is linked to stimulus-outcome-based motivational behavior.The CSTC circuits are connected to other brain structures, such as the fronto-parietal network, which has a role in the coordination of cognitive control, and the fronto-limbic circuit (from the ventromedial prefrontal cortex to the amygdala to the thalamus), which is important in fear extinction and the processing of emotionally salient stimuli (Shephard et

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Section: Discussionsupporting

confidence: 89%

Affecting OCD

Rickelt¹

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“…Furthermore, nursing professionals were the ones who most added stigma because they were protagonists in the fight against the disease. Conceptually, obsessive compulsive disorder is a chronic neuropsychiatric condition, generated by high loads of anxiety, being characterized by repetitive and intrusive thoughts, accompanied by negative mood or distress, which generate ritualistic behaviors in order to prevent feared events (36) . Considering the findings, other reflections are relevant regarding the probability of acquiring psychological distress related to the historical evolution of nursing in the face of the main epidemics experienced in the country and in the world.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with psychopathological symptoms among nurses at a university hospital

Lima

Santos

et al. 2023

Rev. Bras. Enferm.

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Objectives: to analyze the factors associated with psychopathological symptoms among nurses at a university hospital. Methods: a cross-sectional study developed at a university hospital in Pernambuco, in which 90 nurses participated. A questionnaire with social and professional characteristics and the Symptom Assessment Scale were used. Results: an association was found between the variable changing profession and the presence of characteristic symptoms of psychoticism, somatization and anxiety among nurses. Conclusions: the emergence of psychopathological symptoms has influenced nurses’ desire to search for another profession. This evidence reinforces the need for greater investments in better working conditions and welcoming actions in the work environment, in order to provide a better quality of professional life and promote the health of these workers.

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“…Esse entendimento está diretamente relacionado às relações de trabalho com a saúde desses profissionais. Carga horária/sem (h) 30-40horas 0,45 ± 0,33 0,30 (0,10; 0,60) 0,50 (0,30; 0,90) 0,50 (0,20; 0,70) 0,10 (0,00; 0,50) >40-60horas 0,49 ± 0,45 0,45 (0,30; 0,80) 0,50 (0,20; 0,80) 0,40 (0,20; 0,80) 0,20 (0,00; 0,40) > 60horas 0,39 ± 0,35 0,50 (0,10; 0,85) 0,50 (0,25; 0,85) 0,20 (0,15; 0,60) 0,10 (0,00; 0,50) Valor de p 0,612 * 0,259 ** 0,986 ** 0,258 ** 0,821 ** Mudar de profissão Sim 0,59± 0,55 0,70 (0,30; 1,00) 0,60 (0,40; 0,90) 0,60 (0,40; 0,90) 0,30 (0,10; 0,60) Não 0,41± 0,33 0,40 (0,10; 0,60) 0,50 (0,20; 0,80) 0,40 (0,20; 0,60) 0,10 (0,00; 0,30) Valor de p 0,008 A 0,006 B 0,129 B 0,032 B 0,049 B Vínculos 1 0,41± 0,40 0,30 (0,10; 0,63) 0,50 (0,28; 0,93) 0,50 (0,20; 0,73) 0,10 (0,00; 0,43) 2 ou mais 0,47± 0,36 0,40 (0,23; 0,78) 0,50 (0,30; 0,80) 0,40 (0,20; 0,78) 0,20 (0,00; 0,40) Valor de p 0,533 A 0,145 B 0,907 B 0,851 B 0,844 B Atividade Assistência direta 0,44± 0,35 0,40 (0,18; 0,70) 0,50 (0,20; 0,80) 0,40 (0,20; 0,70) 0,20 (0,00; 0,40) Assistência indireta 0,48± 0,39 0,40 (0,20; 0,70) 0,40 (0,30; 0,88) 0,40 (0,23; 0,80) 0,20 (0,00; 0,40) Valor de p 0,561 A 0,734 B 0,646 B 0,422 B 0,976 B Uso de medicação Sim 0,45±0,38 0,40 (0,20; 0,70) 0,50 (0,30; 0,90) 0,40 (0,20; 0,80) 0,20 (0,00; 0,40) Não 0,47±0,35 0,40 (0,20; 0,80) 0,50 (0,20; 0,80) 0,40 (0,30; 0,60) 0,20 (0,00; 0,40 A evidência da dimensão obsessividade/compulsividade pode corresponder ao comportamento que tem como origem as práticas seguras adotadas com maior rigor neste contexto de pandemia, além do medo da contaminação pela COVID-19.Ainda, os profissionais de enfermagem foram os que mais agregaram estigma por serem protagonistas no combate à doença.Conceitualmente, o transtorno obsessivo compulsivo é uma condição neuropsiquiátrica crônica gerado por altas cargas de ansiedade, sendo caracterizado por pensamentos repetitivos e intrusivos, acompanhados por humor negativo ou angústia, que geram comportamentos ritualísticos, a fim de prevenir eventos temidos (36) .…”

Section: Discussionunclassified

Fatores associados aos sintomas psicopatológicos entre enfermeiros de um hospital universitário

Lima

Santos

et al. 2023

Rev. Bras. Enferm.

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RESUMO Objetivos: analisar os fatores associados aos sintomas psicopatológicos entre enfermeiros de um hospital universitário. Métodos: estudo transversal, desenvolvido em um hospital universitário de Pernambuco, em que participaram 90 enfermeiros. Foi utilizado um questionário com características sociais e profissiográficas e a Escala de Avaliação de Sintomas. Resultados: foi constatada a associação entre a variável mudar de profissão e a presença de sintomas característicos de psicoticismo, somatização e ansiedade entre os enfermeiros. Conclusões: o surgimento de sintomas psicopatológicos tem influenciado no desejo de enfermeiros na busca por outra profissão. Essa evidência reforça a necessidade de maiores investimentos em melhores condições de trabalho e ações de acolhimento no ambiente laboral, a fim de proporcionar uma melhor qualidade de vida profissional e favorecer a promoção a saúde desses trabalhadores.

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A dimensional perspective on the genetics of obsessive-compulsive disorder

Cited by 21 publications

References 143 publications

Affecting OCD

Affecting OCD

Factors associated with psychopathological symptoms among nurses at a university hospital

Fatores associados aos sintomas psicopatológicos entre enfermeiros de um hospital universitário

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