A digital reference model of the human bronchial tree

Schmidt, Andreas H.; Zidowitz, Stephan; Kriete, Andres; Denhard, Thorsten; Kraß, Stefan; Peitgen, Heinz‐Otto

doi:10.1016/j.compmedimag.2004.01.001

Cited by 98 publications

(84 citation statements)

References 21 publications

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“…The lower bronchial and bronchiole airways were generated by randomly selecting airways from the human bronchial tree dataset of Schmidt et al [18] (see Fig. 4).…”

Section: Lung Geometry/mesh Constructionmentioning

confidence: 99%

“…The test model is based on patient-specific CT-scan data of the extrathoracic region and a lower airway dataset available in the open literature [18]. In contrast to [15] and [16], the geometry considered here includes asymmetric branching angles, variability of intragenerational airway lengths and diameters, noncylindrical airways, and incomplete resolution of airway flowpaths to the terminal outlets.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficient, Physiologically Realistic Lung Airflow Simulations

Walters

Burgreen

Lavallee

et al. 2011

IEEE Trans. Biomed. Eng.

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Abstract-One of the key challenges for computational fluid dynamics (CFD) simulations of human lung airflow is the sheer size and complexity of the complete, multiscale geometry of the bronchopulmonary tree. Since 3-D CFD simulations of the full airway tree are currently intractable, researchers have proposed reduced geometry models in which multiple airway paths are truncated downstream of the first few generations. This paper investigates a recently proposed method for closing the CFD model by application of physiologically correct boundary conditions at truncated outlets. A realistic, reduced geometry model of the lung airway based on CT data has been constructed up to generation 18, including extrathoracic, bronchi, and bronchiole regions. Results indicate that the new method yields reasonable results for pressure drop through the airway, at a small fraction of the cost of fully resolved simulations.

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“…The lower bronchial and bronchiole airways were generated by randomly selecting airways from the human bronchial tree dataset of Schmidt et al [18] (see Fig. 4).…”

Section: Lung Geometry/mesh Constructionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficient, Physiologically Realistic Lung Airflow Simulations

Walters

Burgreen

Lavallee

et al. 2011

IEEE Trans. Biomed. Eng.

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show abstract

“…The measurement was performed on a realistic replica of human airways, whose dimensions and development have been published in [10]. The geometry of airways used for fabrication of our model comes from a computed tomography (CT) of the tracheobronchial tree excised from a cadaver (for detail please see Schmidt et al [11]), which was combined with a 3D scan of the wax cast of the so called Lovelace Respiratory Research Institute (LRRI) "A" model [12]. The combined airway geometry was then processed in a computer aided design (CAD) software Rhinoceros to form a segmented physical model of human lungs (Fig.…”

Section: Methodsmentioning

confidence: 99%

Prediction of localized aerosol deposition in a realistic replica of human airways using experimental data and numerical simulation

et al. 2017

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Abstract. The presence of aerosol deposition hot-spots in human airways presumably contributes to development of various diseases. The overall aerosol deposition in human lungs can be predicted with sufficient accuracy nowadays. However, the prediction of localized aerosol deposition poses arduous challenge, namely in diseased lungs. Numerical simulation is considered to be a promising tool for the successful prediction. Yet, the validation of such simulations is difficult to perform, as not enough experimental data acquired using realistic airway replicas is available. This paper presents a first comparison of localized deposition measurement and simulation performed on the identical realistic geometry. The analysis indicates that both approaches yield similar results for low Reynolds number flows.

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“…The final geometry was created by merging of the geometry published by Schmidt et al [23], which contains the airways from the trachea up to 17 th generation of branching with geometry of larynx and trachea obtained by CT in St. Anna University Hospital in Brno. Obtaining full geometry using the CT scan failed because of poor image quality due to movements caused by a heartbeat.…”

Section: Transparent Realistic Model Of Human Airwaymentioning

confidence: 99%