A digital health platform for assisting in diagnosing and monitoring disease progression of COVID-19: An adjuvant approach for augmenting the anti-viral response and reducing the immune-mediated target organ damage (Preprint)

Abstract

BACKGROUND The outbreak of a coronavirus disease in 2019 (COVID-19) which is associated with respiratory-related illness and high mortality presents a major worldwide need. Problems of information availability to health care providers; difficulties in diagnosis and disease prognosis; and a lack of monitoring tools are some of the obstacles faced by the clinical community. Most importantly, the lack of valid therapies makes the pandemic a devastating universal problem. Current information points to a concept of dysregulation of the immune system which is unable to mount an effective anti-viral response, and on the other hand induces an uncontrolled immune-mediated response manifesting as ARDS, myocarditis and hepatitis. OBJECTIVE In the present paper we describe a novel platform for providing information to physicians, and assisting in diagnosis and monitoring of patients with COVID-19. METHODS Review of the relevant literature publications RESULTS An adjuvant approach is presented, using compounds that can boost a beneficial anti-viral immune response while reducing the immune-mediated target organ damage associated with the virus. CONCLUSIONS Ensuring a prolonged beneficial effect is performed by implementing algorithm-based individualized variability measures into the treatment regimen.