A differential involvement of voltage-sensitive Ca2+ channel (VSCC) in mediation of the neuroprotective action of NMDA antagonists.

ABSTRACT-The effects of nebracetam were investigated on N-methyl-D-aspartate (NMDA) receptor and voltage-operated Ca 2+ channels (VOCC)-mediated neural dysfunction by directly monitoring the real-time dynamics of dopamine released from rat striatal slices. Nebracetam (105 and 10-4 M) com pletely protected against striatal dopaminergic impairment induced by L-glutamate and NMDA, respec tively. BAY K-8644-evoked striatal dysfunction was not blocked by nebracetam (10-4 M). Therefore, nebracetam seems to produce a neuroprotective action by interacting, at least in part, with NMDA receptor-operated Ca 2+ channels.

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Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices

Kataoka

Níwa

Koizumi

et al. 1992

Japanese Journal of Pharmacology

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A differential involvement of voltage-sensitive Ca2+ channel (VSCC) in mediation of the neuroprotective action of NMDA antagonists.

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Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices

Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices

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