A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats

Lecca, Daniele; Piras, Giovanna; Driscoll, Peter; Giorgi, Osvaldo; Corda, Maria Giuseppa

doi:10.1016/j.neuropharm.2003.11.011

Cited by 73 publications

(70 citation statements)

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“…As a result, the total amount of cocaine consumed by RHA rats over the 20 test sessions (D150 mg/kg) was significantly larger than that consumed by RLA rats (D110 mg/kg). Thus, RHA rats appear to be more responsive than RLA rats to the reinforcing effects of cocaine, in keeping with the notion that these lines differ in the behavioral and neurochemical responses to the acute and repeated exposure to a variety of addictive drugs, including ethanol, morphine and psychostimulants (Fernández-Teruel et al, 2002;Lecca et al, 2004;Giorgi et al, 2007).…”

Section: Discussionsupporting

confidence: 72%

“…Thus, compared with their RLA counterparts, RHA rats display a more robust sensation/novelty seeking profile, as well as higher baseline levels of impulsivity, and a marked preference for and intake of natural and drug rewards (Zeier et al, 1978;Siegel et al 1993;Escorihuela et al 1999;Giorgi et al 1999;Fernández-Teruel et al 2002). The phenotypic traits that distinguish these lines are at least partly determined by differences in the functional properties of their central dopaminergic pathways: (1) stressors and anxiogenic drugs activate the mesocortical dopaminergic projection of RHA, but not RLA, rats (D'Angio et al, 1988;Corda et al, 1997;Giorgi et al, 2003); (2) RHA rats have a higher density of D-1 dopamine (DA) receptors in the NAc (Giorgi et al, 1994); (3) the acute administration of psychostimulants and morphine causes a larger increment in motor activity and in DA output in the shell than in the core of the NAc of RHA, but not RLA, rats (Lecca et al, 2004); (4) the repeated administration of psychostimulants and morphine induces behavioral sensitization only in RHA rats Corda et al, 2005;Giorgi et al, 2005a); (5) in sensitized RHA rats, a subsequent challenge with these drugs elicits a more robust increment in DA output in the NAc-core, associated with an attenuated dopaminergic response in the NAc-shell, whereas these adaptive changes are not observed in sensitization-resistant RLA rats (Giorgi et al, 2005b(Giorgi et al, , 2007.…”

Section: Introductionmentioning

confidence: 99%

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The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The phenotypic traits of the RHA line predict higher susceptibility, compared with RLA rats, to the reinforcing properties of addictive substances like cocaine. The present study was designed to compare the acquisition, maintenance, reinstatement of drugseeking after long-term extinction, and reacquisition of intravenous cocaine self-administration (SA) behavior in the Roman lines. Compared with RLA rats, the rates of responding during cocaine SA acquisition were higher, extinction from cocaine SA was prolonged, and drug-induced reinstatement of cocaine-seeking behavior was more robust in RHA rats. Moreover, only RHA rats reacquired extinguished lever-pressing activity when a low reinforcing dose of cocaine was available. These findings are consistent with the view that subjects with genetically determined high responsiveness to the acute and chronic (ie, sensitizing) effects of psychostimulants, such as RHA rats, also display a higher propensity to self -administer cocaine. Further comparative studies in the Roman lines, using SA paradigms that distinguish mere drug-taking from the compulsive and uncontrolled drug use that characterizes addiction in humans, may eventually help to characterize the relationships among genotype, temperament traits, and neurobiological mechanisms involved in the individual vulnerability to cocaine addiction.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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“…Moreover, the relationship between monoamine levels and impulsivity depends on the particular impulsive behavior evaluated (Winstanley et al, 2006, for review). Convergent evidence suggests that monoaminergic (at least DA and 5-HT) functional differences in the mesolimbic-mesocortical systems and related areas mediate the impulsivity-related behavioral traits that distinguish the Roman rat lines/ strains, including differential sensitivity to the effects of (and preference for) drugs of abuse (for reviews, see Charnay et al, 1995;Driscoll et al, 1980;Fattore et al, 2009;Fernández-Teruel et al, 2002a;Giorgi et al, 1994Giorgi et al, , 2003Giorgi et al, , 2007Guitart-Masip et al, 2006a, b, 2008aKulikov et al, 1995;Lecca et al, 2004). Collectively, the neurochemical findings reported in these studies suggest a relatively increased function (or tone) of DA and 5-HT neurotransmission in the RHA rat line/strain relative to RLA animals.…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

131

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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“…These findings suggest that RLA rats represent a valid genetic model to investigate the neural circuitry and molecular mechanisms underlying stress‐induced depression and, more specifically, to study depression associated with anxiety symptoms. Multidisciplinary studies aimed at identifying the central neuronal circuits involved in the above‐mentioned behavioral differences across the Roman lines have shown that their divergent phenotypic traits may be accounted for, at least in part, by differences in the functional responses of their central monoaminergic systems (D'Angiò, Serrano, Driscoll, & Scatton, 1988; Giorgi, Lecca, Piras, Driscoll, & Corda, 2003; Giorgi, Piras, Lecca, & Corda, 2005; Giorgi et al., 1994; Giorgi, Piras, et al., 2003 Giorgi et al., 2007, 2015; Lecca, Piras, Driscoll, Giorgi, & Corda, 2004; Sanna et al., 2015; Tournier et al., 2013). …”

Section: Introductionmentioning

confidence: 99%

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

et al. 2017

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IntroductionThe selective breeding of Roman High‐ (RHA) and Low‐Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress‐induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders.Materials and MethodsWestern blot (WB) and immunohistochemistry were used to investigate the basal immunochemical occurrence of brain‐derived neurotrophic factor (BDNF) and its high‐affinity tyrosine‐kinase receptor trkB in the dorsal and ventral hippocampus of adult RHA and RLA rats.Results WB analysis indicated that the optical density of BDNF‐ and trkB‐positive bands in the dorsal hippocampus is, respectively, 48% and 25% lower in RLA versus RHA rats. Densitometric analysis of BDNF‐ and trkB‐like immunoreactivity (LI) in brain sections showed that BDNF‐LI is 24% to 34% lower in the different sectors of the Ammon's horn of RLA versus RHA rats, whereas line‐related differences are observed in the dentate gyrus (DG) only in the ventral hippocampus. As for trkB‐LI, significant differences are observed only in the dorsal hippocampus, where density is 23% lower in the DG of RLA versus RHA rats, while no differences across lines occur in the Ammon's horn.ConclusionThese findings support the hypothesis that a reduced BDNF/trkB signaling in the hippocampus of RLA versus RHA rats may contribute to their more pronounced vulnerability to stress‐induced depression.

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A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats

Cited by 73 publications

References 42 publications

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

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