A different outlook at the phenotype-function relationships of T cell subpopulations: Fundamental and clinical implications

Naor, David

doi:10.1016/0090-1229(92)90064-u

Cited by 10 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The helper function of T cells has been associated with the CD4 + surface receptor, and the CD8 + receptor has been associated with the cytotoxic/ suppressor function. However, helper T cells are found in both subsets as well as cytotoxic and suppressor cells (Naor 1992). These CD8 + cells may be involved in the development of periradicular lesions in the FIV group through unknown mechanisms or by replacing the function of those cells lost to the infection.…”

Section: Discussionmentioning

confidence: 99%

The effect of FIV infection on CD4+ and CD8+ counts in periradicular lesions

Levine¹,

Witherspoon²,

Gutmann³

et al. 2001

Int Endod J

View full text Add to dashboard Cite

Aim The purpose of this study was to elucidate whether a decrease/increase in T‐cell populations is present in the development of periradicular disease in the immunocompromised feline model. Methodology Eight cats were immunosuppressed with steroids prior to infection with feline immunodeficiency virus (FIV). Another eight cats, age and sex matched littermates, were monitored and tested at equivalent periods of time and served as uninoculated, seronegative controls. Periradicular lesions were induced using local bacterial inoculations into the pulp of the canine teeth and assessed after one‐ and four‐week periods, corresponding to the acute and chronic stages of the periradicular disease. Block sections were obtained and specimens were prepared for H & E and immunohistochemical staining for CD4+ and CD8+ receptors. Cells were quantified using a computer imaging system and data analysed using generalized estimating equation (GEE) regression models. Results Significantly lower CD4+ counts and CD4+/CD8+ ratios were observed at all time periods in the periradicular region of the FIV group (P = 0.0006). No significant difference in CD8+ counts was observed between the two groups. In both groups there was a significant difference in the CD4+ counts between one week and baseline, and 1 week and 4 weeks. There was no significant difference between baseline and 4 weeks for either group. Conclusion FIV infection reflected decreased CD4+ counts at the periradicular level, however, inflammation and progression of the lesion, appeared to be comparable to the non‐immunocompromised controls.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of FIV infection on CD4+ and CD8+ counts in periradicular lesions

Levine¹,

Witherspoon²,

Gutmann³

et al. 2001

Int Endod J

View full text Add to dashboard Cite

show abstract

“…Because soluble antigens need to be processed and presented on the surface of autologous APC in association with MHC class II to CD4 T lymphocyte (rev. in Naor, 1992), this is the most sensitive index of dysfuction of these lymphocyte. That is defect is not secondary to an impairment in the capacity of APC to process/present antigenic peptides was shown by experiments in which soluble antigen-sensitised APC from HIV-infected monozygotic twins were able to stimulate CD4 TH of the HIVuninfected twins Blauvelt et al, 1995); (2) Defects in TH function in response to stimulation with allogeneic lymphocytes in a mixed lymphocyte reaction (MLR) appear next, in patients in whom the ability to respond to soluble antigens was lost earlier (Clerici et al, 1989).…”

Section: Cell Mediated Immunity Is Defective In Hiv Infectionmentioning

confidence: 99%

Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression

et al. 1997

View full text Add to dashboard Cite

The progressive loss of CD4 T lymphocyte is patognomonic of Human Immunodeficiency Virus (HIV) infection and results in immunodeficiency and the appearance of acquired immunodeficiency syndrome (AIDS)-defining pathologies. Although a percentage of CD4 T lymphocytes is destroyed directly by HIV infection, a much higher proportion of lymphocytes remains uninfected and therefore must be destroyed by mechanisms not directly involving viral infection. One such mechanism is apoptotic T cell death (ATCD). ATCD in HIV infection has been shown to be: 1) secondary to cross-linking of CD4 by viral proteins; 2) mediated by both APO-1/Fas and lymphotoxin (LT); and 3) differentially modulated by type 1 and type 2 cytokines. We will briefly analyze the experimental evidences suggesting that ATCD contributes significantly to the immunopathogenesis of HIV/AIDS via depletion of CD4 + T cells.

show abstract

Cytokine Patterns Associated with Chronic Fatigue Syndrome

Sredni

1997

Chronic Fatigue Syndrome

View full text Add to dashboard Cite

A different outlook at the phenotype-function relationships of T cell subpopulations: Fundamental and clinical implications

Cited by 10 publications

References 63 publications

The effect of FIV infection on CD4+ and CD8+ counts in periradicular lesions

The effect of FIV infection on CD4+ and CD8+ counts in periradicular lesions

Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression

Cytokine Patterns Associated with Chronic Fatigue Syndrome

Contact Info

Product

Resources

About