A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron

Sharma, Garima; Sharma, Amit; Kim, Inhae; Cha, Dong Gon; Kim, Somi; Park, Eun Seo; Noh, Jae Gyun; Lee, Juhee; Ku, Ja Hyeon; Choi, Yoon Ha; Kong, JungHo; Lee, Haena; Ko, Haeun; Lee, Juhun; Notaro, Anna; Hong, Seol Hee; Rhee, Joon Haeng; Kim, Sang Geon; De Castro, Cristina; Molinaro, Antonio; Shin, Kunyoo; Kim, Sanguk; Kim, Jong Kyoung; Rudra, Dipayan; Im, Sin-Hyeog

doi:10.1038/s41590-024-01816-x

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2024

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Cited by 5 publications

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A microbial iron fist to fight tumors

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Elinav

2024

Nat Immunol

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A microbial iron fist to fight tumors

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Elinav

2024

Nat Immunol

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Bifidobacterium pseudocatenulatumcapsular exopolysaccharide enhances systemic anti-tumour immunity in pre-clinical breast cancer

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Nicklin,

Kujawska

et al. 2024

Preprint

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Gut microbes have merged as powerful regulators of cancer responses, with Bifidobacterium species and strains playing a key role in promoting anti-tumour immunity. While they represent promising candidates for cancer therapeutics, the specific underlying microbial mechanisms driving their efficacy remains poorly understood. In this study, we demonstrate the broad potential of Bifidobacterium species to inhibit breast cancer progression across multiple pre-clinical mouse models. We identify a novel strain, Bifidobacterium pseudocatenulatum 210, which induces systemic anti-tumour immunity and enhances responses to standard-of-care therapies via its cell surface capsular exopolysaccharide (EPS). B. pseudocatenulatum 210 EPS promotes dendritic cell activation and increases systemic cDC1 infiltration, leading to robust CD8+ T cell-mediated anti-tumour activity. Our findings position Bifidobacterium EPS as a novel class of therapeutic compounds with significant potential for cancer treatment.

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Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment

Sun

2024

Gut

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A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron

Cited by 5 publications

References 70 publications

A microbial iron fist to fight tumors

A microbial iron fist to fight tumors

Bifidobacterium pseudocatenulatumcapsular exopolysaccharide enhances systemic anti-tumour immunity in pre-clinical breast cancer

Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment

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