A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study

Theilla, M.; Singer, Pierre; Cohen, Jonathan; DeKeyser, Freda G.

doi:10.1016/j.clnu.2007.06.015

Cited by 60 publications

(55 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 For critical care patients, the evidence is sparse; the role of nutrition in development and treatment of pressure ulcers has been specifically investigated in only 2 studies. 22. 23 In a study 22 of 100 critical care patients with acute lung injury who were receiving mechanical ventilation, development of pressure ulcers was significantly less in patients given an enteral formula enriched with micronutrients, eicosapentaenoic acid, and γ-linolenic acid than in patients given a control enteral formula lacking these nutritional components (χ 2 1 = 3.5; P < .05).…”

mentioning

confidence: 99%

“…22. 23 In a study 22 of 100 critical care patients with acute lung injury who were receiving mechanical ventilation, development of pressure ulcers was significantly less in patients given an enteral formula enriched with micronutrients, eicosapentaenoic acid, and γ-linolenic acid than in patients given a control enteral formula lacking these nutritional components (χ 2 1 = 3.5; P < .05). In a study 23 on the impact of nutrition on healing of pressure ulcers in critical care patients, the progression of stage II or higher pressure ulcers was significantly less in patients given a feeding …”

mentioning

confidence: 99%

See 1 more Smart Citation

Enteral Nutrition in the Prevention and Treatment of Pressure Ulcers in Adult Critical Care Patients

Cox

Rasmussen

2014

Critical Care Nurse

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Enteral Nutrition in the Prevention and Treatment of Pressure Ulcers in Adult Critical Care Patients

Cox

Rasmussen

2014

Critical Care Nurse

View full text Add to dashboard Cite

show abstract

“…Interestingly, we previously showed that the use of the same nutritional formula in critically ill patients with acute respiratory distress syndrome did not result in higher serum levels of vitamins. 7 Although the inflammatory phase is an essential physiological response, 16 excessive release of from added protein and fatty acids is shown in Figure 2. Protein intake did not differ significantly between the 2 groups.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the incidence of new pressure ulcers was significantly reduced by use of the specialized formula. 7 This important finding led us to speculate that this formula might also aid in the healing of new pressure ulcers in the general ICU population. We hypothesized that attenuation of inflammation by the formula would help maintain the immune processes involved in wound healing.…”

mentioning

confidence: 99%

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

Theilla¹,

Schwartz²,

Cohen³

et al. 2012

American Journal of Critical Care

View full text Add to dashboard Cite

Background Pressure ulcers are an important source of morbidity and suffering for patients and a formidable burden on caregivers. Objectives To assess the impact of a feeding formula enriched with fish oil on healing of preexisting pressure ulcers and serum levels of C-reactive protein in critical care patients. Methods Adult patients with pressure ulcers grade II or higher were randomly allocated to receive either a formula enriched with fish oil or an isocaloric control formula. Wound healing was assessed by using the Pressure Ulcer Scale for Healing tool on days 7, 14, and 28. Blood levels of C-reactive protein were measured on days 0, 7, and 14. Results Baseline demographics did not differ between the study (n = 20) and the control (n = 20) groups. The mean score on the ulcer healing tool increased significantly (P = .02) from day 0 to day 28 in the control group (from 9.25 [SD, 2.12] to 10.75 [SD, 3.41]) compared with the study group (from 9.10 [SD, 2.84] to 9.40 [SD, 3.72]). Mean levels of C-reactive protein decreased significantly (P = .02) from day 0 to day 14 in the study group (from 191 [SD, 104.4] mg/L to 111.7 [SD, 97.8] mg/L) compared with the control group (from 145 [SD, 90] mg/L to 139 [SD, 62] mg/L). Conclusion Administration of a feeding formula enriched with fish oil was associated with decreased progression of pressure ulcers and a decrease in blood concentrations of C-reactive protein.

show abstract

“…Pero hasta el momento, los estudios han sido contradictorios en demostrar la eficacia clínica de las dietas con combinaciones de grasas ricas en ácidos eicosapentanoico (EPA), docosahexaenoico (DHA), γ-linolénico (GLA) y antioxidantes en el complejo mundo de la LPA y el SDRA (42)(43)(44)(45)(46)(47)(48)(49)(50)(51). La heterogenicidad de los estudios, la ausencia de información sobre el manejo clíni-co, la utilización de fórmulas con mezclas de farmaconutrientes y la disparidad de resultados hacen que no se pueda recomendar el uso rutinario de estas fórmulas enterales (52).…”

Section: Soporte Nutricional En El Paciente Con Lpa Y Sdra (Fig 1)unclassified

Nuestros grandes olvidados, los enfermos respiratorios crónicos

Laguna

2017

Nutr Hosp

View full text Add to dashboard Cite

Lung's own properties make that nutritional support, besides covering the requirements can modulate its infl ammatory response. Lung tissue has a low glucose stock. Fatty acids are the main energy producer of type II pneumocytes, which use them in order to form phospholipids, essential for surfactant whose creation and release decrease in acute lung injury (ALI). Glutamine is a good substratum for endocrine cells and type II pneumocytes. Due to high nutritional risk, it is important its assessments in disorders as COPD and acute respiratory distress syndrome (ADRS). Indirect calorimetry values the effect of ventilation and nutritional support, avoiding overfeeding. Hypophosphatemia and refeeding syndrome are frequent and need to be avoided because of their morbidity. In critically ill patients, malnutrition can lead to respiratory failure and increasing mechanical ventilation time. To avoid hypercapnia in weaning, glucose levels should be controlled. High lipids/carbohydrates ratio do not show usefulness in COPD neither mechanical ventilation removal. ALI patients benefi ciate from an early start and the volume administered. Enteral nutrition with high fatty acids ratio (EPA, DHA and γ-linolenic acid) and antioxidants do not show any superiority. Omega-3 fatty acid in parenteral nutrition could modulate infl ammation and immunosuppression in a positive manner. The use of glutamine, vitamins or antioxidants in these patients could be justifi ed. Nuestros grandes olvidados, los enfermos respiratorios crónicos ResumenLas peculiaridades del pulmón hacen que el soporte nutricional, además de cubrir los requerimientos, pueda modular su respuesta infl amatoria. El pulmón tiene mínima capacidad de almacenar glucosa. Los lípidos son el sustrato energético de elección de los neumocitos tipo II que los utilizan para formar fosfolípidos, componentes esenciales del surfactante. Su síntesis y liberación disminuyen en la lesión pulmonar aguda (LPA). La glutamina es un buen sustrato para las células endoteliales y los neumocitos tipo II. La valoración nutricional de los pacientes con EPOC y SDRA es fundamental dado su alto riesgo nutricional. La calorimetría indirecta evalúa la respuesta del soporte nutricional y ventilatorio, evitando la sobrenutrición. La hipofosfatemia del síndrome de realimentación es frecuente y debe evitarse por la morbilidad que conlleva. En críticos, la desnutrición puede mantener la insufi ciencia respiratoria y prolongar el tiempo de ventilación mecánica (VM). En fase de weaning se deberían controlar los aportes de glucosa para evitar la retención de CO 2 . Fórmulas con un alto cociente grasas/hidratos de carbono no han demostrado una clara utilidad en el paciente EPOC ni en la retirada de la VM. Los pacientes con LPA se benefi cian del soporte nutricional precoz y del control del aporte de volumen. Las dietas enterales con alto contenido en grasas (EPA, DHA y γ-linolénico) y antioxidantes no han demostrado superioridad. En nutrición parenteral, las emulsiones con mayor contenido de ácidos gr...

show abstract

A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study

Cited by 60 publications

References 22 publications

Enteral Nutrition in the Prevention and Treatment of Pressure Ulcers in Adult Critical Care Patients

Enteral Nutrition in the Prevention and Treatment of Pressure Ulcers in Adult Critical Care Patients

Impact of a Nutritional Formula Enriched in Fish Oil and Micronutrients on Pressure Ulcers in Critical Care Patients

Nuestros grandes olvidados, los enfermos respiratorios crónicos

Contact Info

Product

Resources

About