“…Expanding the capabilities of either technique to bridge this gap is a subject of future interest. Decreasing the pressurization time of NIC to increase strain rate seems to be a viable experimental protocol to accomplish this goal (105). Distinguishing cavitation from fracture.…”
Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. Cavitation rheology is a field emerging from the development of a suite of materials characterization, damage quantification, and therapeutic techniques that exploit the physical principles of cavitation. Cavitation rheology is inherently complex and broad in scope with wide-ranging applications in the biology, chemistry, materials, and mechanics communities. This perspective aims to drive collaboration among these communities and guide discussion by defining a common core of highpriority goals while highlighting emerging opportunities in the field of cavitation rheology. A brief overview of the mechanics and dynamics of cavitation in soft matter is presented. This overview is followed by a discussion of the overarching goals of cavitation rheology and an overview of common experimental techniques. The larger unmet needs and challenges of cavitation in soft matter are then presented alongside specific opportunities for researchers from different disciplines to contribute to the field. soft solids | traumatic brain injury | TBI | rheology | bubble Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. While predominantly studied in fluids, cavitation is also an origin of damage in soft materials, including biological tissues. Examples of cavitation in fluids and soft solids are shown in Fig. 1 A-C. As one key example, strong evidence suggests that cavitation occurs in the brain during sudden impacts, leading to traumatic brain injury (TBI) (3). Research on this life-impacting injury and its relation to cavitation has accelerated in recent years (4-8). A broader and deeper understanding of cavitation within soft matter is necessary to navigate the complex paths that lead to damage in the brain and other soft materials. Cavitation in fluids has been studied extensively since Rayleigh's (9) formulation in 1917, which predicted that the maximum pressure in a cavitating liquid is proportional to the far-field pressure and inversely proportional to the cavity size. As surface energy
“…Expanding the capabilities of either technique to bridge this gap is a subject of future interest. Decreasing the pressurization time of NIC to increase strain rate seems to be a viable experimental protocol to accomplish this goal (105). Distinguishing cavitation from fracture.…”
Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. Cavitation rheology is a field emerging from the development of a suite of materials characterization, damage quantification, and therapeutic techniques that exploit the physical principles of cavitation. Cavitation rheology is inherently complex and broad in scope with wide-ranging applications in the biology, chemistry, materials, and mechanics communities. This perspective aims to drive collaboration among these communities and guide discussion by defining a common core of highpriority goals while highlighting emerging opportunities in the field of cavitation rheology. A brief overview of the mechanics and dynamics of cavitation in soft matter is presented. This overview is followed by a discussion of the overarching goals of cavitation rheology and an overview of common experimental techniques. The larger unmet needs and challenges of cavitation in soft matter are then presented alongside specific opportunities for researchers from different disciplines to contribute to the field. soft solids | traumatic brain injury | TBI | rheology | bubble Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. While predominantly studied in fluids, cavitation is also an origin of damage in soft materials, including biological tissues. Examples of cavitation in fluids and soft solids are shown in Fig. 1 A-C. As one key example, strong evidence suggests that cavitation occurs in the brain during sudden impacts, leading to traumatic brain injury (TBI) (3). Research on this life-impacting injury and its relation to cavitation has accelerated in recent years (4-8). A broader and deeper understanding of cavitation within soft matter is necessary to navigate the complex paths that lead to damage in the brain and other soft materials. Cavitation in fluids has been studied extensively since Rayleigh's (9) formulation in 1917, which predicted that the maximum pressure in a cavitating liquid is proportional to the far-field pressure and inversely proportional to the cavity size. As surface energy
“…The technique has been successfully applied to characterize elastic modulus and surface energy of soft matter including gels 31,32 , biological tissues 33 , and individual cell spheroids 34 . Extensions of the the pressure-induced cavitation rheology have been developed in recent years to investigate dynamic fracture 35,36 and viscoelasticity at moderate strain rates up to 1 s −1 37 . However, the applicability of these techniques to characterize material viscoelasticity at a higher range of strain rates is limited by the increased contribution from inertia and cavity asymmetry not captured by the governing theories.…”
An understanding of inertial cavitation is crucial for biological and engineering applications such as non-invasive tissue surgeries and the mitigation of potential blast injuries. However, predictive modeling of inertial cavitation in biological tissues is hindered by the difficulties of characterizing fluids and soft materials at high strain rates, and the computational cost of calibrating biologically-relevant viscoelastic models. By incorporating a reduced-order model of inertial cavitation in the inertial microcavitation rheometry (IMR) experimental technique, we present an efficient procedure to inversely characterize viscoelastic material subjected to inertial cavitation. Instead of brute-force iteration of constitutive model parameters, the present approach directly estimates the elastic and viscous moduli according to the sizedependent scaling of bubble dynamics. Through reproduction of numerical-simulated inertial cavitation kinematics and experimental characterization of benchmark materials, we demonstrate that the proposed framework can determine the complex rate-dependent properties of soft solid with a small number of numerical simulations. The availability of this procedure will broaden the applicability of IMR for localized characterization of fluids and soft biological materials at high strain rates.
“…To address this challenge, significant effort in recent years has gone towards developing new characterization techniques capable of extracting information on the high strain-rate mechanical behavior of soft materials -including small-scale ballistic cavitation, 18 laser-induced particle impact testing, 19 shear impact testing, 20 and Inertial Microcavitation Rheometry (IMR), [21][22][23][24][25] which is the focus of the present work. IMR belongs to a class of cavitation-based material characterization techniques 26 -including needle-induced cavitation 11,12,18 and volume-controlled cavity expansion [13][14][15] -and is unique in its ability to mechanically characterize soft materials at high strain rates greater than 10 3 s À1 . In IMR, a single spherical microbubble is generated inside a soft material using either a spatially-focused pulsed laser 21,27 or high-amplitude focused ultrasound, 23,28,29 inducing high strain-rate (410 3 s À1 ) deformation in the surrounding material.…”
Inertial Microcavitation Rheometry (IMR) is a promising tool for characterizing the mechanical behavior of soft materials at high strain rates. In IMR, an isolated, spherical microbubble is generated inside a...
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