Spray-drying technique which is an uninterrupted process of drying slurry is becoming an important apparatus in the production of thermal spray powders. There are several hundred commercial powders specifically developed for the various spray drying process; metals, metals alloys, ceramics, carbides and polymers. Thermal spray powders are produce using a mixed type spray dryer, as it gives higher temperature exposure and more residence time of spray to evaporate in the drying chamber. To improve the performance and prediction of process parameters of spray dryer, the CFD analysis was done, the Standard K-є, Reliable K-є and Reynolds Stress Model models were used to predict velocity profiles and temperature profile for the drying chamber. Different model results were compared, studied and compared with experimental results. The Reliable K-є method is found to have good agreement with the experiment data to predict the velocity and, mimicked the temperature profile of the drying chamber.