A Device for Fast Mechanical Clot Retrieval From Intracranial Arteries (Phenox Clot Retriever)

Henkes, Hans; Reinartz, J; Lowens, Stephan; Miloslavski, E.; Roth, Christian; Reith, Wolfgang; Kühne, D.

doi:10.1385/ncc:5:2:134

Cited by 40 publications

(31 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The smallest version is capable of recanalizing vessel diameters well below 2 mm such as the distal MCA branches. 54 This device became available for the treatment of patients with acute ischemic stroke in Europe in October 2006.…”

Section: Ia Mechanical Approaches In Acute Ischemic Strokementioning

confidence: 99%

Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data

Nogueira¹,

Schwamm²,

Hirsch³

2009

AJNR Am J Neuroradiol

121

111

View full text Add to dashboard Cite

SUMMARY:Despite years of research and pioneering clinical work, stroke remains a massive public health concern. Since 1996, we have lived in the era of US Food and Drug AdministrationϪapproved intravenous (IV) recombinant tissue plasminogen activator (rtPA). This treatment, despite its promise, continues to exhibit its limitations. Endovascular therapy has several theoretic advantages over IV rtPA, including site specificity, longer treatment windows, and higher recanalization rates. In this article, we will review the various pharmacologic strategies for acute stroke treatment, providing both a historic context and the state of the art. The drugs will be classified on the basis of their theoretic rationale for therapy. Next, we will review the various devices and strategies for mechanical revascularization with an aim toward comprehensiveness. These range from wire disruption of thrombus to preclinical trials for novel mechanical solutions. This first installment of this 2-part series will end with an analysis of retrograde reperfusion techniques.

show abstract

Section: Ia Mechanical Approaches In Acute Ischemic Strokementioning

confidence: 99%

Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data

Nogueira¹,

Schwamm²,

Hirsch³

2009

AJNR Am J Neuroradiol

121

111

View full text Add to dashboard Cite

show abstract

“…This device is also known to cause vasospasm and vessel dissection. Reported recanalisation rates for loop-shaped tools, a corkscrew-shaped nitinol coil (Merci Retriever, Concentric Inc., CA) and a nitinol basket are in the range of 50% [13]. In phase 1 of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, which included 28 patients, successful recanalisation with mechanical embolectomy was achieved in 12 (43%) patients, with additional intra-arterial tPA in 18 (64%) patients [14].…”

Section: Discussionmentioning

confidence: 99%

Treatment of acute middle cerebral artery occlusion with a Solitaire AB stent: preliminary experience

Nayak¹,

Ladurner²,

Killer³

2010

BJR

View full text Add to dashboard Cite

ABSTRACT. We report our initial experience with a Solitaire AB neurovascular remodeling stent device in performing cerebral embolectomy in seven patients presenting to our institution with acute stroke who were resistant to iv thrombolytic drug treatment. The main inclusion criteria were: National Institutes of Health Stroke Scale (NIHSS) score >10; treatment performed within 8 h from the onset of symptoms and no large hypodensity on CT; and occlusion of a major cerebral artery on the CT angiogram. An admission and a post-interventional NIHSS score were calculated for all patients by two different neurologists. Efficacy was assessed radiologically by posttreatment thrombolysis in myocardial infarction (TIMI) scores and clinically by a 30-day Modified Rankin Scale (MRS) score. The mean duration of neurointerventional treatment was 84 min. All interventions were successful, with TIMI scores of 2 or 3 achieved in 100% of patients. There was one procedural complication in our series owing to a self-detached stent and one patient had a small asymptomatic basal ganglia haemorrhage. There was improvement of more than 4 points on the NIHSS score in 5 (72%) of the patients following treatment, of whom 4 (57%) had a 30-day MRS score of #2. The use of a Solitaire stent in acute stroke was safe, time-efficient and encouraging; however, a larger sample size will be required to further evaluate the use of this device, which could benefit a significant number of stroke patients.

show abstract

“…The Phenox CRC device is a modification of the Phenox pCR device, 8,14,15 adding an additional self-expanding nitinol cage at the proximal end of a brushlike device. In the present study, the novel device was found to be effective for recanalization with an overall complete recanalization rate (TICI/ TIMI 3) of 86.7%.…”

Section: Discussionmentioning

confidence: 99%

“…8,14,15 It consists of a highly flexible nitinol/platinumalloy core wire compound. This wire compound holds radially oriented polyamide microfilaments and is marked by radiodense markers on the proximal and distal ends.…”

Section: Thrombectomy Devicementioning

confidence: 99%

“…12 Each device advocated so far has a different design and mechanical properties in terms of thrombus-device interaction, 12,13 and systematic evaluation is therefore crucial. The Phenox CRC (Phenox, Bochum, Germany) device is a modification of the pCR device, 8,14,15 adding an additional self-expanding cage at the proximal end of a brushlike device. To date, no systematic evaluation of the device is available in the literature.…”

mentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Evaluation of the Phenox CRC Mechanical Thrombectomy Device in a Swine Model of Acute Vessel Occlusion

Mordasini¹,

Hiller²,

Brekenfeld³

et al. 2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:Mechanical thrombectomy in ischemic stroke is of increasing interest as it is a promising strategy for fast and efficient recanalization. Several thrombectomy devices have been introduced to the armentarium of mechanical thrombectomy. Currently, new devices are under development and are continuously added to the neurointerventional tool box. Each device advocated so far has a different design and mechanical properties in terms of thrombus-device interaction. Therefore, a systematic evaluation under standardized conditions in vivo of these new devices is needed. The purpose of this study was to evaluate the efficiency, thrombus-device interaction, and potential complications of the novel Phenox CRC for distal mechanical thrombectomy in vivo.

show abstract

A Device for Fast Mechanical Clot Retrieval From Intracranial Arteries (Phenox Clot Retriever)

Abstract: The phenox clot retriever, a flexible microfilament pattern, might be a useful supplement to the repertoire of currently available devices for endovascular intracranial thrombectomy.

Cited by 40 publications

References 9 publications

Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data

Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data

Treatment of acute middle cerebral artery occlusion with a Solitaire AB stent: preliminary experience

In Vivo Evaluation of the Phenox CRC Mechanical Thrombectomy Device in a Swine Model of Acute Vessel Occlusion

Contact Info

Product

Resources

About