A detector for track-nanodosimetry

Nardo, L. De; Alkaa, A.; Khamphan, C.; Conte, V.; Colautti, P.; Ségur, P.; Tornielli, G.

doi:10.1016/s0168-9002(01)01989-1

Cited by 51 publications

(20 citation statements)

References 24 publications

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“…The vertical axis of the volume V is perpendicular to the central line of the particle beam. More details on the track-detector can be found in De Nardo et al (2002b).…”

Section: Experimental Set-up and Methodsmentioning

confidence: 99%

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Track structure of light ions: experiments and simulations

et al. 2012

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To study the track structure of light ions, a measuring device has been developed at the Legnaro National Laboratory of INFN, which can be used to investigate separately the penumbra region of particle tracks and the trackcore region, which is a few nanometres in diameter. The device is based on single-electron counting techniques by means of a gas detector; it simulates a 'nanometre-sized' biological volume of about 20 nm in diameter that can be moved with respect to a narrow particle beam to measure the ionizationcluster-size distributions caused within the target volume by the passage of single primary particles, as a function of the impact parameter. To investigate the ionization-cluster-size formation caused by primary particles of medical interest when they penetrate through or pass by the target volume at a specified impact parameter, measurements and Monte Carlo simulations were performed for 20 MeV protons, 16 MeV deuterons, 48 MeV 6 Li-ions, 26.7 MeV 7 Li-ions and 96 MeV 12 C-ions. The detailed analysis of the resulting distributions showed that in the track-core region their shape is mainly determined by the mean free ionization path length of the primary particles, whereas in the penumbra region the shape of the distributions is almost independent of the impact parameter, and also of the particle type and velocity.

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“…The vertical axis of the volume V is perpendicular to the central line of the particle beam. More details on the track-detector can be found in De Nardo et al (2002b).…”

Section: Experimental Set-up and Methodsmentioning

confidence: 99%

“…The white square represents the 'nominal' cylindrical target volume V of 3.7 mm in width and 3.7 mm in height. The yellow circles represent the confining electrode rings of 0.1 mm in diameter.the end of the drift column(De Nardo et al 2002b). A picture of the efficiency map concerning ε V × ε drift is given infigure 7.…”

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confidence: 99%

Track structure of light ions: experiments and simulations

et al. 2012

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“…The Jet Counter at NCBJ detects positive ions produced by primary particles passing centrally through a pulse of nitrogen gas simulating biological target sizes of about 2 nm and 20 nm by adjusting the density of molecules [17,18]. The StarTrack Counter at INFN detects electrons generated in a sensitive volume of propane equivalent to a 20 nm biological target intersected by the primary particle track at a defined distance from the target centre [19,20]. The PTB Ion Counter also detects positive ions produced in a gas target corresponding to a target of about 2 nm in diameter [21,22].…”

Section: Nanodosimetrymentioning

confidence: 99%

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Rabus

Hilgers

Sharpe

et al. 2014

EPJ Web of Conferences

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Abstract. Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

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“…[12][13][14][15][16] Therefore, a more suitable tool for track structure description may be nanodosimetry. 17 In nanodosimetry, [18][19][20][21][22][23][24][25] the track structure of charged particles is characterized by the frequency distributions of the ionization cluster size (ICS), that is, the number of ionizations produced within a target volume in nanoscale. Direct measurements of the distributions can be conducted using nanodosimeters, while only limited number of nanodosimeters under restricted measurement conditions are working now.…”

Section: Introductionmentioning

confidence: 99%

“…Direct measurements of the distributions can be conducted using nanodosimeters, while only limited number of nanodosimeters under restricted measurement conditions are working now. 21,22,26,27 Nanodosimetry can also be simulated by means of track structure Monte Carlo (MC) codes such as PTB code 28,29 and Geant4 DNA. [30][31][32][33] However, such simulations are extremely time-consuming and cannot be applied to the clinically relevant carbon-ion beams directly.…”

Section: Introductionmentioning

confidence: 99%

Nanodosimetric quantities and RBE of a clinically relevant carbon‐ion beam

Dai

Liu

et al. 2019

Medical Physics

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Purpose Although carbon‐ion therapy is becoming increasingly attractive to the treatment of tumors, details about the ionization pattern formed by therapeutic carbon‐ion beam in tissue have not been fully investigated. In this work, systematic calculations for the nanodosimetric quantities and relative biological effectiveness (RBE) of a clinically relevant carbon‐ion beam were studied for the first time. Methods The method combining both track structure and condensed history Monte Carlo (MC) simulations was adopted to calculate the nanodosimetric quantities. Fragments and energy spectra at different positions of the radiation field of a clinically relevant carbon‐ion pencil beam were generated by means of MC simulations in water. Nanodosimetric quantities such as mean ionization cluster size (M1), the first moment of conditional cluster size (M1C2), cumulative probability (F2), and conditional cumulative probability (F3C2) at these positions were then acquired based on the spectra and the pre‐calculated nanodosimetric database created by track structure MC simulations. What’s more, a novel approach to calculate RBE based on the said nanodosimetric quantities was introduced. The RBE calculations were then conducted for the carbon‐ion beam at different water‐equivalent depths. Results Lateral distributions at various water‐equivalent depths of both the nanodosimetric quantities and RBE values were obtained. The values of M1, M1C2, F2, and F3C2 were 1.49, 2.67, 0.30, and 0.38 at the plateau at the beam central axis and maximized at 2.79, 5.69, 0.47, and 0.68 at the depths around the Bragg peak, respectively. At a given depth, M1 and F2 decreased laterally with increasing the distance to the beam central axis while M1C2 and F3C2 remained nearly unchanged at first and then decreased except for M1C2 at the rising edge of the Bragg peak. The calculated RBE values were 1.07 at the plateau and 3.13 around the Bragg peak. Good agreement between the calculated RBE values and experimental data was obtained. Conclusions Different nanodosimetric quantities feature the track structure of therapeutic carbon‐ion beam in different manners. Detailed ionization patterns generated by carbon‐ion beam could be characterized by nanodosimetric quantities. Moreover the combined method adopted in this work to calculate nanodosimetric quantities is not only valid but also convenient. Nanodosimetric quantities are significantly helpful for the RBE calculations in carbon‐ion therapy.

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A detector for track-nanodosimetry

Cited by 51 publications

References 24 publications

Track structure of light ions: experiments and simulations

Track structure of light ions: experiments and simulations

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Nanodosimetric quantities and RBE of a clinically relevant carbon‐ion beam

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