A detection method for unified chromatography: Ion mobility monitoring

Hill, Herbert H.; Louis, Robert H. St.; Morrissey, Mark A.; Shumate, Christopher B.; Siems, William F.; McMinn, Dennis G.

doi:10.1002/jhrc.1240150703

Cited by 17 publications

(4 citation statements)

References 13 publications

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“…The group led by Hill has pioneered the use of the IMD in all types of chromatographies, including SFC. The versatility of the IMD is illustrated in a review by Hill and McMinn (192) and by the articles by Hill et al (193,194). Most modified CO2 mobile phases and alternate chlorofluorocarbon mobile phases had little effect on the positive and negative reactant ion pattern (193).…”

Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

“…The versatility of the IMD is illustrated in a review by Hill and McMinn (192) and by the articles by Hill et al (193,194). Most modified CO2 mobile phases and alternate chlorofluorocarbon mobile phases had little effect on the positive and negative reactant ion pattern (193). Hill and Tarver illustrated the potential utility of SFC/Fourier transform IMD with a wide variety of applications (195).…”

Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

See 1 more Smart Citation

Supercritical Fluid Chromatography and Extraction

Chester¹,

Pinkston²,

Raynie³

1994

Anal. Chem.

163

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Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

Section: Sfc Instrumentation Techniques and Performancementioning

confidence: 99%

Supercritical Fluid Chromatography and Extraction

Chester¹,

Pinkston²,

Raynie³

1994

Anal. Chem.

163

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“…Thus, this research also explored the possibility of using electrospray ionization to produce solvent ions, which would then form a secondary ionization source for gas-phase samples. The potential of IMS for unified chromatography has been previously reported [15]. The application of ESI-IMS to gas-phase samples could extend this concept further by developing a single detector capable of operation after gas, supercritical fluid, and liquid chromatographic separation.…”

Section: Introductionmentioning

confidence: 99%

Analytical merit of electrospray ion mobility spectrometry as a chromatographic detector

Chen

Hill

Wittmer

1994

J Microcolumn Separations

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Abstract. Electrospray ionization ion mobility spectrometry (ESI-IMS), a technique which has only recently become analytically useful, has been evaluated for use as a detector for microbore liquid chromatography and capillary electrophoresis. Figures of merit for ESI-IMS were determined. Detection limits as low as 1 x mol s-l were measured, with a linear response range of 3 to 4 orders of magnitude and with reproducibility within 3 % (relative standard deviation of peak area). Gradient elution with water/methanol mobile phase did not perturb chromatographic baseline, compound response, or product ion mobility. Both positive and negative ion mobility spectra for more than 30 compounds demonstrated the sensitivity of ESI-IMS response to a wide range of analytes. Finally, the concept of using ESI-IMS as an ionization source for gasphase samples was presented, potentially unifying detector application for both gas and liquid chromatography.

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“…To test our hypothesis, a commercially available electrospray ionization high-performance ion mobility spectrometry (ESI-HPIMS) was used. In a series of publications and presentations from 1987 to 1992, Hill applied electrospray ionization as a sample introduction technique for introducing nonvolatile compounds into an ion mobility spectrometer. − The types of ESI and their advantages were discussed elsewhere . Today ESI is one of the most important and powerful analytical technique because of its ability to analyze nonvolatile compounds.…”

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confidence: 99%

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

Kanu

Leal

2016

Anal. Chem.

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A new approach to reduce the false-positive responses commonly encountered in the field when drugs and explosives are detected is reported for an electrospray ionization high-performance ion mobility spectrometry (ESI-HPIMS). In this article, we report on the combination of reduced mobility and the width-at-half-height of a peak to give a new parameter called conditional reduced mobility (CRM). It was found that the CRM was capable of differentiating between real drugs peaks from that of a false-positive peak and may help to reduce false-positive rates. This effect was demonstrated using 11 drugs (amphetamine, cannabidiol, cocaine, codeine, heroine, methamphetamine, morphine, phentermine, L-phenylepherine, proglitazone, and rosiglitazone) and seven interferences chosen from off-the-shelf products. This report determined and compared CRM, resolving power (R(m)), and diffusion-limited conditional theoretical reduced mobility (DLCTRM) for ESI-HPIMS. The most important parameters for determining CRM are reduced mobility and width-at-half-height of a peak. There is a specific optimum voltage, gate pulse width, resolving power, and now CRM for each ion. DLCTRM indicate the optimum reduced mobility that is not normally possible under field conditions. CRM predicts the condition at which a target compound can be differentiated from a false-positive response. This was possible because different ions exhibits different drifting patterns and hence a different peak broadening phenomenon inside an ion mobility tube. Reduced mobility for target compounds reported were reproducible to within 2% for ESI-HPIMS. The estimated resolving power for the ESI-HPIMS used in this study was 61 ± 0.22. Conditional reduced mobility introduced in this paper show differences between target compounds and false-positive peaks as high as 74%, as was the case for cannabidiol and interference #1 at 70 μs gate pulse width.

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A detection method for unified chromatography: Ion mobility monitoring

Cited by 17 publications

References 13 publications

Supercritical Fluid Chromatography and Extraction

Supercritical Fluid Chromatography and Extraction

Analytical merit of electrospray ion mobility spectrometry as a chromatographic detector

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

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