A Detailed Investigation in the Enhancement Factor of Surface-Enhanced Raman Scattering in Simulation

Advancing clinical cancer care: Unveiling the power of surface‐enhanced Raman spectroscopy

“…This allows for the acquisition of molecular structure information that is not easily attainable with conventional RS. 2,3 During the early stages of malignant tumors, the transformation of cells leads to significant alterations in the structure, conformation, and quantity of intracellular materials. These changes are often challenging to detect using traditional medical imaging techniques.…”

“…To address this issue, SERS was developed, which leverages the local surface plasmon resonance generated by noble metal materials on rough nanostructures to enhance the Raman scattering effect by more than 10 8 times. This allows for the acquisition of molecular structure information that is not easily attainable with conventional RS 2,3 . During the early stages of malignant tumors, the transformation of cells leads to significant alterations in the structure, conformation, and quantity of intracellular materials.…”

“…1 Early tumor screening and diagnosis have shown significant improvements in survival rates, highlighting the importance of timely detection. 2 Population-based early detection programs, such as mammography screening, cervical smears, and fecal immunochemical testing for bowel cancer, have contributed to higher detection rates and reduced mortality. 3 However, these programs have their limitations, including universal application to the majority of the population, the risk of overdiagnosis, and the detection of insignificant diseases.…”

“…According to the latest global cancer data report, cancer has become one of the major health challenges worldwide, with approximately one in five people developing the disease in their lifetime 1 . Early tumor screening and diagnosis have shown significant improvements in survival rates, highlighting the importance of timely detection 2 . Population‐based early detection programs, such as mammography screening, cervical smears, and fecal immunochemical testing for bowel cancer, have contributed to higher detection rates and reduced mortality 3 .…”

A Comprehensive Numerical Study on Fiber Optic SERS Probe Design

“…In the context of the fiber, this phenomenon can enhance the collection efficiency of SERS scattering. While substantial efforts have been directed toward understanding the substrate effect on localized surface plasmon, − studies have not thoroughly examined the field enhancement within the plasmonic hotspot and the subsequent redirection of Raman scattering toward the substrate, specifically within the optical core of the fiber optic SERS probe. This oversight is critical considering these factors greatly influence the efficiency of SERS signal collection through optical fibers.…”