A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment

Bouwmans, C.; Lintsen, Bea M.E.; Eijkemans, Marinus J.C.; Habbema, J. Dik F.; Braat, D.D.M.; Hakkaart, L.

doi:10.1016/j.fertnstert.2007.03.003

Cited by 62 publications

(47 citation statements)

References 18 publications

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“…COH is an essential part of IVF and is needed to obtain oocytes that can be fertilized in vitro. The high cost of IVF is partly due to the use of expensive drugs, such as gonadotrophins, needed for COH [34,35]. In clinical practice, physicians often rely on clinical experience and personal judgment when selecting an appropriate starting dose of follicle stimulation hormone (FSH).…”

Section: Discussionmentioning

confidence: 99%

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Sun

Wang

Sun

et al. 2014

J Assist Reprod Genet

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Purpose To evaluate basal testosterone (T) levels in women undergoing in vitro fertilization (IVF) cycles and examine the association between basal T levels and ovarian response or IVF pregnancy outcome. Methods We retrospectively analyzed 1413 infertile Chinese women undergoing their first IVF treatment at our institution's reproductive center from March 2011 to May 2013. The basal testosterone (T) levels in women undergoing in vitro fertilization (IVF) and the relationship between basal T levels and ovarian response or IVF pregnancy outcome were determined. These patients did not have polycystic ovary syndrome (PCOS) or endometriosis, and were treated with a long luteal down-regulation protocol. Subjects were divided into 2 groups according to basal testosterone (T) levels: Group 1, basal T values <20 ng/dl (n=473), and Group 2, basal T values >20 ng/dl (n=940). We evaluated the association of basal T levels with ovarian response and IVF outcome in the two groups. Results In this study, BMI, basal follicle-stimulating hormone (FSH) levels, basal luteinizing hormone (LH) levels, antral follicle count (AFC), days of stimulation, total gonadotrophin dose, basal FSH/LH ratio, and the number of follicles >14 mm were significantly different (P<0.05) between the two groups. Basal T level positively correlated with ovarian reserve function, number of follicles >14 mm on human chorionic gonadotrophin (HCG) day, and total gonadotropin dose. However, basal T levels play no role in predicting IVF pregnancy outcome. Conclusion Basal T level can be used as a good predictor for ovarian response and the number of large follicles on HCG day. Additionally, we may use basal T level as a marker to predict FSH dosage. In general women, lower level of T might relate with potential poor ovarian response. However, based on our data, basal T levels do not predict pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Sun

Wang

Sun

et al. 2014

J Assist Reprod Genet

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“…In contrast, taking into consideration the fact that in many IVF centers worldwide cost may be an important issue, using a syringe to manually create the negative pressure, at least in cases of emergency, may be an attractive alternative (3). Considering that the cost of oocyte retrieval is estimated to be at approximately 220 Euro (3,4), safeguarding the amount required for a pump replacement, may contribute to wider provision of IVF services under the provision of proving that manual suction leads to uncomplicated oocyte retrieval. …”

Section: Discussionmentioning

confidence: 99%

Egg recovery completed with a “manually-created” negative pressure is still an option in cases of emergency or “low-cost” in vitro fertilization?

Kalampokas

Maheswari

2015

J Turkish German Gynecol Assoc

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In the past (early 1980s), follicle aspiration with manual pressure was the common procedure; nevertheless, it has been reported that follicular aspiration using a syringe suction system may damage the zona pellucida (1). This was not the case in our patient despite the lower fertilization rate that we had achieved (3/8 eggs were fertilized); however, the fact that only one good quality embryo was obtained may present a complication for the procedure. A disadvantage of the method may be the fact that in cases of application of manual suction, we cannot apply flushing of the aspirated follicles, which is a technique used for oocyte aspiration in our center. Nevertheless, one may say that this is not an obligatory applied technique, and recent research suggests that follicles should not be flushed in cases of normal responders, as in our case (2). In contrast, taking into consideration the fact that in many IVF centers worldwide cost may be an important issue, using a syringe to manually create the negative pressure, at least in cases of emergency, may be an attractive alternative (3). Considering that the cost of oocyte retrieval is estimated to be at approximately 220 Euro (3, 4), safeguarding the amount required for a pump replacement, may contribute to wider provision of IVF services under the provision of proving that manual suction leads to uncomplicated oocyte retrieval.

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“…No cases postoperative pelvic infection was recorded.. ```````Discussion:-Uterine factors are responsible for 2-3% of infertility cases and intrauterine lesions more common in infertile women (40-50%) (12) . IVF is an expensive treatment results in a successful outcome in only a third of treatment cycles (13) . It has been suggested that unsuspected intrauterine abnormalities may negatively affect the uterine environment and the likelihood of achieving an ongoing pregnancy (14) .This study included 100 infertile patients who had hysteroscopy for different indications, 36 patients (36%) were found to have abnormal hysteroscopic findings despite normal HSG and TV/US, hormonal profile, semen analysis.…”

Section: Hysteroscopic Procedurementioning

confidence: 99%

Diagnostic Hysteroscopy as a Primary Tool in Basic Infertility Workup.

Eloraby¹,

Elnory²,

Eldeen³

et al. 2016

IJAR

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A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment

Cited by 62 publications

References 18 publications

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Egg recovery completed with a “manually-created” negative pressure is still an option in cases of emergency or “low-cost” in vitro fertilization?

Diagnostic Hysteroscopy as a Primary Tool in Basic Infertility Workup.

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