A Design Study of the Neutron Irradiation Facility for Boron Neutron Capture Therapy

Oka, Yoshiaki; Yanagisawa, Ichiroh; An, Shigehiro

doi:10.13182/nt81-a32809

Cited by 13 publications

(3 citation statements)

References 11 publications

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“…HiSPANoS facility is the first ABNS in Spain. This facility provides different neutron fields in continuouswave employing 7 Li(p,n) 7 Be and 2 H(d,n) 3 He reactions. Since 2019, a new pulsed mode and a new experimental Time-Of-Flight (TOF) line are available [16,17],…”

Section: Experimental Setup and Measurementmentioning

confidence: 99%

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New data for the definition of neutron beams for Boron Neutron Capture Therapy

Macías,

Fernández,

Praena

2020

Preprint

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Boron Neutron Capture Therapy (BNCT) is a neutron radiotherapy used to treat tumours cells previously doping with Boron-10. This therapy requires an epithermal neutron beam for the treatment of deep tumours and a thermal beam for shallow ones. Thanks to recent high-current commercial accelerators, Accelerator-Based Neutron Sources (ABNS) are competitive option for providing therapeutic neutron beams in hospitals. In this work, the neutron field generated by the 7 Li(p,n) 7 Be reaction at 1950 keV is studied as neutron source in ABNS, being measured by the Time-Of-Flight (TOF) technique at HiSPANoS facility (Spain). Moreover, two Beam Shaping Assemblies (BSA) for deep and shallow tumour treatment, which are specially designed for the 1950 keV neutron field, are evaluated for BNCT via Monte Carlo simulations (MCNP). Results in agreement with the International Atomic Energy Agency (IAEA) figures of merit endorse the use of this neutron field for BNCT.

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Section: Experimental Setup and Measurementmentioning

confidence: 99%

“…Their neutron sources have been limited to specially modified nuclear reactors. Therefore, low-energy high-intensity particle accelerators have been developed for BNCT since the 1980s [2,3,4,5]. Several countries are developing accelerators to produce epithermal neutron beams for BNCT.…”

Section: Introductionmentioning

confidence: 99%

New data for the definition of neutron beams for Boron Neutron Capture Therapy

Macías,

Fernández,

Praena

2020

Preprint

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“…However, a beam ranging in energy through the eV to low keV range could be suitable for NCT provided that the fast neutron and gamma contamination levels are not too high. Oka et al (1981) in their design study of an epithermal beam, chose a mixture of heavy water and aluminium as being suitable for attenuating the fast neutron flex relative to the epithermal flux. Noonan and Russell (1983) used an aluminidsulphur filter for their epithermal beam facility in the Georgia Institute of Technology research reactor.…”

Section: Introductionmentioning

confidence: 99%

Neutron‐Induced Gamma Dose From a Reactor Beam Filter for Boron Neutron Capture Therapy

Harrington

1989

Pigment Cell Research

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For the boron neutron capture therapy (NCT) of deep-seated metastatic melanoma, an epithermal (up to a few keV energy) neutron beam from a reactor horizontal facility could be useful if the inherent contamination from fast neutrons and gamma rays could be minimised. Calculations for ANSTO's 10 MW research reactor HIFAR have shown that, even though a filter material such as AlF3 attenuates the fast neutron dose, the beam quality improvement is counteracted by a relative increase in the gamma dose because of the gammas arising from neutron captures in the filter material, particularly the aluminium. The aluminium gammas, most of which arise from thermal neutron capture, are hard and cannot be attenuated by lead or bismuth without comparable attenuation of the epithermal neutron flux. Addition of an absorber such as 6Li to the AlF3 filter was investigated as a means of reducing the hard gamma dose, but the improvement in beam quality was small and at considerable cost to dose intensity. Dose characteristics calculations confirmed the superiority of a tangential beam over a radial beam with better results from an unfiltered tangential beam than from an AlF3 filter in a radial beam. This study showed conclusively that assessments of filter assemblies based on the effect of individual components on either the neutron or gamma dose in isolation are inadequate. In assessing any epithermal neutron filter, thermal neutron shield, and gamma shield combination, the total effect of each on the neutron, gamma, and boron-10 dose must be considered.

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An Experimental Study of the Moderator Assembly for a Low-Energy Proton Accelerator Neutron Irradiation Facility for BNCT

Wang

Blue

1990

Neutron Beam Design, Development, and Performance for Neutron Capture Therapy

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A Design Study of the Neutron Irradiation Facility for Boron Neutron Capture Therapy

Cited by 13 publications

References 11 publications

New data for the definition of neutron beams for Boron Neutron Capture Therapy

New data for the definition of neutron beams for Boron Neutron Capture Therapy

Neutron‐Induced Gamma Dose From a Reactor Beam Filter for Boron Neutron Capture Therapy

An Experimental Study of the Moderator Assembly for a Low-Energy Proton Accelerator Neutron Irradiation Facility for BNCT

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