A design method based on Bayesian decision for routing-based digital microfluidic biochips

Shi, Jinlong; Fu, Ping; Zheng, Wenbin

doi:10.1039/d1an02103f

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…References [ 21 , 22 ] proposed an arbitrary angle routing algorithm. In response to storage issues, References [ 23 , 24 ] proposed a distributed channel storage method. References [ 25 , 26 , 27 ] proposed a weighted sum algorithm for the total length of microchannels.…”

Section: Introductionmentioning

confidence: 99%

Structural Optimization Design of Microfluidic Chips Based on Fast Sequence Pair Algorithm

Wu,

Sun,

Almuaalemi

et al. 2023

Micromachines

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The market for microfluidic chips is experiencing significant growth; however, their development is hindered by a complex design process and low efficiency. Enhancing microfluidic chips’ design quality and efficiency has emerged as an integral approach to foster their advancement. Currently, the existing structural design schemes lack careful consideration regarding the impact of chip area, microchannel length, and the number of intersections on chip design. This inadequacy leads to redundant chip structures resulting from the separation of layout and wiring design. This study proposes a structural optimization method for microfluidic chips to address these issues utilizing a simulated annealing algorithm. The simulated annealing algorithm generates an initial solution in advance using the fast sequence pair algorithm. Subsequently, an improved simulated annealing algorithm is employed to obtain the optimal solution for the device layout. During the wiring stage, an advanced wiring method is used to designate the high wiring area, thereby increasing the success rate of microfluidic chip wiring. Furthermore, the connection between layout and routing is reinforced through an improved layout adjustment method, which reduces the length of microchannels and the number of intersections. Finally, the effectiveness of the structural optimization approach is validated through six sets of test cases, successfully achieving the objective of enhancing the design quality of microfluidic chips.

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Section: Introductionmentioning

confidence: 99%

Structural Optimization Design of Microfluidic Chips Based on Fast Sequence Pair Algorithm

Wu,

Sun,

Almuaalemi

et al. 2023

Micromachines

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show abstract

“…In recent years, the design and application of biochips based on microfluidic technologies have attracted extensive attention from researchers in China and elsewhere [ 1 , 2 , 3 ]. Among them, the microfluidic separation technology has become an effective tool for cell detections [ 4 , 5 ] and disease diagnosis [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)

Duan

Zhang

2022

Biosensors

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The precise control of target particles (20 µm) at different inclination angles θiis achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small particles in a fixed region of the flow channel, but also avoid the large deflection of some small particles at the end of the array. The addition of the buffer area can effectively improve the separation purity of the chip. By exploring the manufacturing process of the microchannel substrate, an adjustable tilted-angle scheme is proposed. The use of ataTSAW makes the acoustic field area in the microchannel have no corner effect region. Through experiments, when the signal source frequency was 33.6 MHz, and the flow rate was 20 µL/min, our designed chip could capture 20 µm particles when θi= 5°. The deflection of 20 µm particles can be realized when θi= 15°–45°. The precise dynamic separation of 20 µm particles can be achieved when θi= 25°–45°, and the separation purity and efficiency were 97% and 100%, respectively.

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Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips

Dong,

Guo,

Lian

et al. 2024

Journal of King Saud University - Computer and Information Scie

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A design method based on Bayesian decision for routing-based digital microfluidic biochips

Abstract: With the continuous application and development of digital microfluidic technology in various fields, many researchers have studied the design of digital microfluidic chips. Module-based chip design methods greatly simplify the...

Cited by 5 publications

References 41 publications

Structural Optimization Design of Microfluidic Chips Based on Fast Sequence Pair Algorithm

Structural Optimization Design of Microfluidic Chips Based on Fast Sequence Pair Algorithm

A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)

Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips

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