A desensitization protocol for the mAb cetuximab

Jerath, Maya R.; Kwan, Mildred; Kannarkat, Mily; Mirakhur, Beloo; Carey, Lisa A.; Valgus, John M.; Platts-Mills, Thomas A.E.; Tarrant, Teresa K.

doi:10.1016/j.jaci.2008.09.046

Cited by 39 publications

(18 citation statements)

References 5 publications

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“…Avoidance is so successful in this condition that it is difficult to consider desensitization as an option for the “red meat” cases. By contrast, there are cases in which cetuximab is indicated, and a successful desensitization regime has been published [35]. …”

Section: Discussionmentioning

confidence: 99%

Allergenicity of Carbohydrates and Their Role in Anaphylactic Events

Commins

Platts-Mills

2009

Curr Allergy Asthma Rep

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The IgE response to pollen allergens often includes IgE antibodies specific for glycosylation motifs on the pollen proteins. These oligosaccharides are present on many different species and are known as cross-reactive carbohydrate determinants. However, IgE antibodies to plant-derived cross-reactive carbohydrate determinants seem to have only minor clinical significance and have not been related to anaphylaxis. Recently, two novel forms of anaphylaxis have become apparent in the southeastern United States: 1) reactions during the first infusion of the monoclonal antibody cetuximab and 2) adult-onset delayed anaphylaxis to red meat. Detailed investigation of serum antibodies established that in both cases, the patients had IgE antibodies specific for the mammalian oligosaccharide galactose alpha-1, 3-galactose. Identification of these cases is helpful in avoiding infusion reactions to cetuximab or recommending specific avoidance of meat derived from mammals. However, the current evidence does not fully resolve why these IgE antibodies are so common in the Southeast or why the anaphylactic or urticarial reactions to red meat are delayed.

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Section: Discussionmentioning

confidence: 99%

Allergenicity of Carbohydrates and Their Role in Anaphylactic Events

Commins

Platts-Mills

2009

Curr Allergy Asthma Rep

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“…The reason for this variation is unknown. The first published desensitization to cetuximab was a case report describing a female with metastatic breast cancer and pre-existing anticetuximab-specific IgE [26]. A five-solution, 20-step protocol was used with premedications of prednisone at 12 and 1 h before infusion and diphenhydramine 30 min pre-infusion.…”

Section: Cetuximabmentioning

confidence: 99%

Allergy to monoclonal antibodies: cutting-edge desensitization methods for cutting-edge therapies

Hong

Bankova

Cahill

et al. 2012

Expert Review of Clinical Immunology

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“…This process has been invaluable in allowing the use of life-saving and disease-modifying medications in situations in which there is no acceptable treatment alternative. Desensitization has been described in case reports or small series for rituximab, 27 infliximab, [28][29][30] trastuzumab, 31,32 muronomab, 33 cetuximab, 34 and omalizumab. 12 No desensitizationrelated deaths have been reported.…”

mentioning

confidence: 99%