A descriptive study of the factors associated with damage in Malaysian patients with lupus nephritis

Shaharir, Syahrul Sazliyana; Ghafor, Abdul Halim Abdul; Said, Mohd Fuaad; Kong, Norella C T

doi:10.1177/0961203313518624

Cited by 15 publications

(26 citation statements)

References 37 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the Pakistani lupus study showed higher renal damage of 37.5% [21]. The discrepancies can be explained by other various factors such as different treatment protocol and a wide spectrum of different histological renal changes which have influence in determining the outcome of LN [35,36]. …”

Section: Discussionmentioning

confidence: 99%

“…Antimalarial agents have been used to treat SLE in over 50 years and since 1990s, there is well-established evidence of its various benefits including anti-thrombotic, anti-hyperlipidaemic, prevention of disease flares and damage in lupus [38]. Our previous studies have also found that the use of HCQ was associated with less disease damage in a small lupus nephritis cohort [35] and was associated with less SDM complication [45]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Damage in the Multiethnic Malaysian Systemic Lupus Erythematosus (SLE) Cohort: Comparison with Other Cohorts Worldwide

et al. 2016

View full text Add to dashboard Cite

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and despite the improvement in the survival in the past few decades, the morbidity due to disease damage remains significant. The objectives of this study were to investigate the disease damagepattern and determine the associated factors of damage in the multi-ethnic Malaysian SLE patients. We consecutively 424SLE patients who attended a consistent follow-up at the National University of Malaysia Medical Centre and Putrajaya Hospital were recruited. Disease damage was assessed using the SLICC/ACR (Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index (SDI) scores. Information on their demographics and disease characteristics were obtained from the clinical record. Univariate analysis was performed and the best model of independent predictors of disease damage was determined by multivariate logistic regression analysis. A total of 182 patients (42.9%) had disease damage (SDI ≥1). A significantly higher number of Indian patients had disease/organ damage and they predominantly developed steroid-induced diabetes mellitus (SDM). Patients with corticosteroid-induced osteoporosis (CIOP) were more likely to be Malayswhile majority of patients who developed malignancy were Chinese (p<0.05). In the univariate and multivariate analyses, disease damage was significantly associated with age, Indian ethnicity, lower mean cumulative C3 level, neuropsychiatry lupus (NPSLE), and antiphospholipid syndrome (APLS). Patients who had ever and early treatment with hydroxychloroquine(HCQ)were less likely to develop disease damage while more patients who had received oral prednisolone ≥1mg/kg daily over 2 weeks had disease damage (p<0.05). In conclusion, there were inter-ethnic differences in the damage pattern and risks among SLE patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Damage in the Multiethnic Malaysian Systemic Lupus Erythematosus (SLE) Cohort: Comparison with Other Cohorts Worldwide

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Hydroxychloroquine has been recognized to be an important immunomodulator treatment that potentially protects against disease damage complicated by the underlying disease or CS treatment . The use of HCQ was demonstrated to be associated with a significantly lower mean serum glucose level among the Baltimore lupus cohort participants, as well as protective effect against abnormal glucose tolerance .…”

Section: Discussionmentioning

confidence: 99%

Steroid‐induced diabetes mellitus in systemic lupus erythematosus patients: analysis from a Malaysian multi‐ethnic lupus cohort

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Disease activity, corticosteroids and immunosuppressive therapy, all contribute to future damage. Cumulative disease activity over years is the single best predictor of damage across all age groups . Certain disease manifestations like renal and neuropsychiatric involvement predict higher damage accrual over time .…”

Section: Damage In Childhood Onset Lupusmentioning

confidence: 99%

“…Certain disease manifestations like renal and neuropsychiatric involvement predict higher damage accrual over time . Other important risk factors for damage are presence of anti‐phospholipid antibodies and acute thrombocytopenia . Therapy‐related damage is maximally contributed by high‐dose corticosteroid therapy in children .…”

Section: Damage In Childhood Onset Lupusmentioning

confidence: 99%

Childhood onset systemic lupus erythematosus: how is it different from adult SLE?

Aggarwal

Srivastava

2014

Int J of Rheum Dis

View full text Add to dashboard Cite

About 20% of systemic lupus erythematosus (SLE) starts in childhood and children have less gender bias in favor of females as compared to adults. Systemic manifestations, nephritis, neuro-psychiatric disease and cytopenias are more common in children at presentation than adults. Since most children develop lupus in their early adolescence, dealing with the diagnosis of an unpredictable lifelong disease during this phase of life is challenging. Physicians must recognise specific medical and social needs of this age group, for optimal long-term outcome. Steroids and immunosuppressive drugs are the cornerstone for treatment in children as with adults with lupus. The outcome has improved considerably with these drugs and 10-year survival is nearly 90%. Due to longer life spans more damage accrues in children as compared to adults. Most of the drugs are associated with significant toxicity and the goal of having a drug which reduces disease activity and damage without hampering normal growth, development and fertility is still an elusive one. The current review focuses on clinical and immunological aspects of childhood SLE and how it differs from adulthood SLE.

show abstract

A descriptive study of the factors associated with damage in Malaysian patients with lupus nephritis

Abstract: Higher maximum daily prednisolone dose predicted disease damage whereas treatment with early HCQ and early CR had a protective role against disease damage.

Cited by 15 publications

References 37 publications

Damage in the Multiethnic Malaysian Systemic Lupus Erythematosus (SLE) Cohort: Comparison with Other Cohorts Worldwide

Damage in the Multiethnic Malaysian Systemic Lupus Erythematosus (SLE) Cohort: Comparison with Other Cohorts Worldwide

Steroid‐induced diabetes mellitus in systemic lupus erythematosus patients: analysis from a Malaysian multi‐ethnic lupus cohort

Childhood onset systemic lupus erythematosus: how is it different from adult SLE?

Contact Info

Product

Resources

About