This retrospective study evaluated 637 forensic autopsy cases of solitary death (kodoku-shi in Japanese) and clarified the present situation of solitary death from the viewpoints of forensic medicine. Of 637 cases who had solitary death, 471 were male and 166 were female, indicating that solitary death predominantly occurred in men. This tendency increased from the age of 40 years in men and 60 years in women. Among the cases, 349 and 199 were natural death and external death, respectively. Ischemic heart disease- and fire-related fatalities were most common in natural death and external death cases, respectively. Suicidal death was more frequent in women than in men. We found two peaks of postmortem interval until finding (PMI-f): < 1 d (182 cases, 28.6%) and 7 days to < 1 month (164 cases, 25.7%). The PMI-f in female cases was significantly shorter than that in male cases. The PMI-f of external death cases was significantly shorter than that of natural death cases. Kushimoto and Shingu, located in the southern part (Kinan region), had a high solitary death rate in forensic autopsy cases because of their small population and high aging rate. Few cases were welfare recipients in solitary death cases in Kinan region (non-urban area), and 23 of 36 welfare recipients lived in Wakayama City, indicating that the economic state would contribute more to the occurrence of solitary death in Wakayama City (urban area). We identified several risk factors and regional characteristics for solitary death cases, and our observations could contribute to administrative welfare measures for the prevention of solitary deaths.