“…For example, the prevalence of PUs/PIs in the general population is 11 of 100 000 people, but rises to approximately 5% and 10% for community and adult/paediatric acute healthcare settings, respectively, rendering this condition as the third most costly disease to treat after cancers and cardiovascular diseases. 1 , 2 , 3 , 4 , 5 , 6 Likewise, the global prevalence of DFUs is approximately 6% (630 per 100 000 diabetic individuals) and the total cost for management of diabetic foot disease ranges from 9 to 13 billion dollars only in the United States, in addition to the cost of managing the diabetes alone. 7 , 8 , 9 It is well established that negative pressure wound therapy (NPWT) is an effective wound care approach for treating and managing these tissue damage conditions.…”