2021
DOI: 10.1186/s12979-021-00241-0
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A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Abstract: Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer’s disease (AD) and cardiovascular disease (CVD). The central dogma of molecular biology demonstrates the conversion of DNA to RNA to the encoded protein. These proteins interact to form complex cell signaling pathways, which perform various biological functions. With prolonged exposure to the environment, the in vivo homeost… Show more

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Cited by 7 publications
(3 citation statements)
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References 69 publications
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“…In order to explore the reasons for the large population of centenarians in longevity areas, different experts analyze the factors affecting longevity from different perspectives. Social and cultural aspects, such as the external environment [3][4] , genetic [5][6][7][8][9] , psychological [10] , nutritional diet [11] and other factors will directly or indirectly affect human life ; from the aspect of natural environment, the aggregation of longevity population proves that the influence of environmental factors on longevity is beyond doubt. The impact of the natural environment on longevity has led experts to analyze it from different perspectives, such as climate [12][13] , geomagnetic field [14] , topography [15] , air pollution [16] , solar radiation [17] and other reasons.…”
Section: Prefacementioning
confidence: 99%
“…In order to explore the reasons for the large population of centenarians in longevity areas, different experts analyze the factors affecting longevity from different perspectives. Social and cultural aspects, such as the external environment [3][4] , genetic [5][6][7][8][9] , psychological [10] , nutritional diet [11] and other factors will directly or indirectly affect human life ; from the aspect of natural environment, the aggregation of longevity population proves that the influence of environmental factors on longevity is beyond doubt. The impact of the natural environment on longevity has led experts to analyze it from different perspectives, such as climate [12][13] , geomagnetic field [14] , topography [15] , air pollution [16] , solar radiation [17] and other reasons.…”
Section: Prefacementioning
confidence: 99%
“…The goal of attaining a longer lifespan and healthy aging has reflected human imagination for centuries, but modern science and technology are beginning to unravel the set of genes that allow longevity and healthy aging to happen. Longevity, referring to the lifespan of humans, and healthspan, which refers to the period of life during which there are low levels of chronic diseases and full functionality in bodily and cognitive functions, are multi-factorial traits [1], [2]. There has been a significant amount of gene research on the role genes and gene pathways play in maintaining cells and shielding them from age-related diseases [3], [4].…”
Section: Introductionmentioning
confidence: 99%
“…Studies have shown that different alleles of the same gene locus affect homeostasis of vascular microenvironment through regulation of expression, which may lead to two opposite outcomes: CVDs and longevity ( 18 ). Longevity and CVD are both interconnected and opposites ( 19 ). Therefore, in our study, besides the normal control, longevity was also used as a negative control to compare with CVD.…”
Section: Introductionmentioning
confidence: 99%