A Dermatologic and Psychiatric Study of Perphenazine (Trilafon) in Dermatology

Treatment of Acute and Chronic Arthralgias With a Tranquilizing Agent (Trilafon) in Addition to Prednisone or Prednisolone

“…The adrenal steroids are used extensively, with notable success, to treat various types of arthritis and soft-tissue rheumatism (1)(2)(3)(4)(5)(6)(7). T'rilafon is an ataractic drug, in the phenothiazine class, which has proved extremely useful in a wide range of emotional problems (8)(9)(10)(11)(12)(13)(14).…”

“…T'rilafon is an ataractic drug, in the phenothiazine class, which has proved extremely useful in a wide range of emotional problems (8)(9)(10)(11)(12)(13)(14).Two groups of patients were selected. Fear of pain often exaggerates the functional limitation of motion far beyond that attributable to organic involvement.…”

“…The adrenal steroids are used extensively, with notable success, to treat various types of arthritis and soft-tissue rheumatism (1-7). T'rilafon is an ataractic drug, in the phenothiazine class, which has proved extremely useful in a wide range of emotional problems (8)(9)(10)(11)(12)(13)(14).Two groups of patients were selected. Group A consisted of 21 ambulatory middle-aged patients with acute and subacute disorders of the joints, chiefly of traumatic origin.…”

Selection of psychotropics in dermatologic practice

“…[57] Subsequent larger studies have described the possible beneficial effect of the phenothiazine FGAs, such as trimeprazine, in pruritus as an adjunct to other primary therapies, possibly related to their tranquilizing properties. [58,59] Hyperhidrosis e effect of antipsychotics on hyperhidrosis is thought to be related to both the peripheral anticholinergic and central anxiolytic effects associated with α-adrenergic receptor blockade. ere are case reports demonstrating efficacy of thioridazine (10-25 mg) and olanzapine (10 mg) for treating hyperhidrosis in late-stage malignancies and low-dose quetiapine (12.5-25 mg) for treating axillary hyperhidrosis.…”

Update on pharmacotherapy in psychodermatological disorders

“…[ 3 ] They are also useful in body focused repetitive behaviors such as trichotillomania (TTM)[ 4 ] and skin picking disorder. [ 5 ] Owing to their multi-receptor action, they are sometimes used in pruritus[ 6 7 ] and hyperhidrosis. [ 8 ] They are divided into first-generation antipsychotics (FGAs; neuroleptics, conventional, or typical anti psychotics) and second-generation anti psychotics (SGAs; atypical).…”