A dereplication strategy for the identification of new phenolic compounds from Anvillea radiata (Coss. &amp; Durieu)

Boukhris, Meryem Alaoui; Destandau, Émilie; Hakmaoui, Ahmed El; Rhaffari, Lhoucine El; Elfakir, Claire

doi:10.1016/j.crci.2016.05.019

Cited by 23 publications

(9 citation statements)

References 16 publications

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“…The Asteraceae plants are rich in hydroxycinnamates representing different structural types [21,31]. Plants of the Inuleae tribe are also good producers of acylquinic acids [31,32,33]. Despite their proven value as active plant metabolites, hydroxycinnamates have remained unexplored constituents of Carpesium sp.…”

Section: Discussionmentioning

confidence: 99%

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

et al. 2019

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Carpesium divaricatum Sieb. & Zucc. has a long history of use as both a medicinal and a food plant. However, except for terpenoids, its chemical constituents have remained poorly investigated. The composition of hydroalcoholic extract from aerial parts of C. divaricatum was analyzed by HPLC-DAD-MSn, revealing the presence of numerous caffeic acid derivatives that were formerly unknown constituents of the plant. In all, 17 compounds, including commonly found chlorogenic acids and rarely occurring butyryl and methylbutyryl tricaffeoylhexaric acids, were tentatively identified. Fractionation of lipophilic extract from cultivated shoots led to the isolation of 12-oxo-phytodienoic acid (12-OPDA), which is a newly identified constituent of the plant. The compound, at concentrations of 0.5, 1.0, and 2.5 μM, significantly reduced IL-8, IL-1β, TNFα, and CCL2 excretion by lipopolysaccharide (LPS)-stimulated human neutrophils. Reactive oxygen species (ROS) production induced by f-MLP was also significantly diminished in the neutrophils pretreated by 12-OPDA. The newly identified constituents of the plant seem to be partly responsible for its pharmacological activity and elevate the value of C. divaricatum as a potential functional food.

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Section: Discussionmentioning

confidence: 99%

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

et al. 2019

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“…30 According to the previous report, peak 1 was provisionally identified as isorhamnetin-3-O-diglucoside. 31 The fragment at m/z 614.2502 of peak 6 suggested that the formula of peak 6 was C 34 H 37 N 3 O 8 . The two fragment ions of peak 6 were at m/z 135.0443 and m/z 119.0502, respectively, suggesting the existence of decarboxylated caffeic acid and p-coumaric acid.…”

Section: Compounds Identification In Rose Bee Pollen Ethanol Extract mentioning

confidence: 99%

Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

et al. 2019

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BACKGROUND: Bee pollen has been regarded as a complete nutritional human dietary supplement but its nutrient absorption and biological effects may be restricted by the complex pollen wall. The aim of this study was to explore the effects of ultrasonic and ball-milling treatment on the release of nutritional components and on in vitro and in vivo antioxidant effects of rose (Rosa rugosa) bee pollen. RESULTS: Bee pollen walls were broken to varying degrees, nutrients were released, and in vitro and in vivo antioxidant effects of bee pollen were improved. The scavenging effects of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 ′ -azinobis(3-ethylbenzothiazolone-6-sulfonic acid) (ABTS) radicals, and oxygen radical absorbance capacity (ORAC) were improved. In aging mice, wall-breaking treatment led to better organ recovery, enhanced superoxide dismutase (SOD) and catalase (CAT) effects, and malondialdehyde (MDA) reduction. Eight compounds of rose bee pollen ethanol extract, including isorhamnetin 3-O-diglucoside and N ′ , N ′′ , N ′′′ -dicaffeoyl p-coumaroyl spermidine were identified by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-QTOF-MS/MS) assay.CONCLUSION: This study showed that ultrasonic treatment had greater wall-disruption effects of bee pollen on nutrient release and antioxidant effect promotion. In conclusion, rose bee pollen, with wall-breaking treatments, may have potential value as an ingredient in functional food processing.

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“…& Dur (Asteraceae), which is mainly distributed in northern Africa, is used by populations and traditional healers in infusions or decoctions of the leaves and flowers to treat a variety of ailments such as chest cold, gastrointestinal, liver and pulmonary disorders, and postprandial hyperglycemia (Hammiche and Maiza, 2006;Ghourri et al, 2013;Fakchich and Elachouri, 2014). Previous phytochemical reports identified two main families in A. radiata aerial parts, i.e., germacranolides such as 9α-hydroxyparthenolide and 8α, 9αepoxyparthenolide isolated in chloroform extracts, and a less abundant fraction of phenolics (e.g., derivatives of dicaffeoylquinic acid), including flavonoids (both glycosides and aglycones) in aqueous/alcoholic extracts (Dendougui et al, 2006;Moumou et al, 2014;Destandau et al, 2015;Boukhris et al, 2016). Aside from these active compounds, saponins, tannins, fatty acids, and various types of secondary metabolites, including sterols, terpenoids, etc.…”

Section: Surveys Of Traditional Saharian Medicines Have Been Conductementioning

confidence: 99%

Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice

Kandouli

Cassien

Mercier

et al. 2017

Journal of Ethnopharmacology

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A dereplication strategy for the identification of new phenolic compounds from Anvillea radiata (Coss. & Durieu)

Cited by 23 publications

References 16 publications

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant

Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components

Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice

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