A delayed neurological syndrome after carbon monoxide intoxication

Mouthon-Reignier, Capucine; Biberon, Julien; Toffol, Bertrand de; Mondon, Karl

doi:10.1016/j.neurol.2017.03.004

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhalation of CO causes severe tissue hypoxia, as it binds to hemoglobin (Hb) more significantly than oxygen [1]. CO poisoning results in tissue hypoxia and direct cell-level damage, and is subsequently associated with serious cardiovascular and neurological complications [2–4]. The mortality rates of patients with CO poisoning at 1 and 3 months are 1.6% and 5.0%, respectively [5], and nearly 40% of the survivors have permanent neurocognitive and emotional deficits.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hyperbaric Oxygen on Neurologic Sequelae and All-Cause Mortality in Patients with Carbon Monoxide Poisoning: A Meta-Analysis of Randomized Controlled Trials

et al. 2019

View full text Add to dashboard Cite

Departmental sources Background: Hyperbaric oxygen (HBO) is used in patients with carbon monoxide (CO) poisoning to prevent the occurrence of delayed neurological sequelae. However, inconsistent results were obtained regarding the treatment effects of HBO. Therefore, the current meta-analysis was conducted based on published randomized controlled trials (RCTs) to determine the effect of HBO on neurologic sequelae and all-cause mortality in patients with CO poisoning. Material/Methods: Electronic databases MedLine, EmBase, and the Cochrane Library were searched for relevant RCTs from inception to March 1, 2019. The pooled relative risks (RRs) and weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the outcomes by using a random-effects model. Sensitivity, subgroup, and publication bias analyses were also conducted. Results: Seven RCTs, including 9 cohorts and a total of 2023 patients with CO poisoning, were enrolled in this study. The summary results revealed that HBO showed an association with lower risk of memory impairment compared to patients receiving normobaric oxygen (NBO), whereas 2 sessions of HBO showed an association with higher risk of memory impairment compared to those who received 1 session of HBO. Moreover, HBO was associated with increased neuropsychologic scores of block design and trail making when compared with NBO. No other significant differences regarding the treatment effects of HBO were observed. Conclusions: These results indicate that HBO therapy significantly reduces the risk of memory impairment compared to NBO, but 2 sessions of HBO might not be better for memory impairment than 1 session of HBO.

show abstract