A Decrease of Calcitonin Serum Concentrations Less Than 50 Percent 30 Minutes after Thyroid Surgery Suggests Incomplete C-Cell Tumor Tissue Removal

Abstract

A rate of calcitonin decrease less than 50% 30 min after thyroidectomy plus central neck lymph node dissection suggests the persistence of tumor tissue in patients operated for MTC. These results indicate that intraoperative calcitonin monitoring may be a useful tool to predict the completeness of surgery in patients with MTC.

CDKN1B V109G polymorphism a new prognostic factor in sporadic medullary thyroid carcinoma

“…The search for RET mutations was performed by amplifying exons 8-16 from germline DNA of all patients and from somatic DNA extracted from 50 available tumor tissues and sequencing the obtained amplicons. All patients were negative for RET germline, whereas RET somatic mutations were found in 13/50 tumor tissue DNA (26%), a percentage slightly lower than that reported in the literature (25,26). They were equally distributed between wild-type-and polymorphism-bearing patients, 25.9 vs 26.1% respectively.…”

“…Serum calcitonin was measured by a commercially available IRMA test (Byk Gulden Italia S.p.A., Milan, Italy) according to the manufacturer's instructions, as previously described (26).…”

Incorporating 131I into a PAMAM (G5.0) dendrimer-conjugate: design of a theranostic nanosensor for medullary thyroid carcinoma

“…40 Consequently, 131 I therapy is not possible without providing a pathway for iodine to be taken up. This experiment uses two synthetic iodine-carriers to transport 131 exposure, the control group and the group of TT cells, which was given Na 131 I, displayed undistinguishable cell viabilities.…”

Medullary thyroid cancer: an update of new guidelines and recent developments

“…Faggiano et al [32] studied 20 patients with sporadic MTC with no pre-operative evidence of lymph node or distant metastases who underwent thyroidectomy and central lymphadenectomy.…”