A decrease in blood cholesterol after gastrostomy could impact survival in ALS

Blasco, Hélène; Patin, Franck; Molinier, S.; Vourc’h, Patrick; Tilly, Olivier Le; Bakkouche, Salah Eddine; Andres, Christian R.; Meininger, Vincent; Couratier, P.; Corcia, P.

doi:10.1038/ejcn.2017.54

Cited by 9 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with a proposed metabolic shift towards an increased peripheral use of lipids in ALS and with the evidence of hypolipidemia in pre‐symptomatic murine ALS models . Evidence that the variations of total cholesterol and low‐density lipoprotein cholesterol concentrations after gastrostomy are negatively associated with survival confirms the involvement of lipid homeostasis in the disease. Also, studies in which ANNs were applied to unravel otherwise hidden connections between variables in sporadic ALS highlighted an association between single nucleotide polymorphisms in genes involved in lipid pathways—including the APOA4 gene ‐ and the disease…”

Section: Discussionsupporting

confidence: 84%

Serum Proteome in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster

Benedetti

Gianazza

Banfi

et al. 2017

Proteomics Clinical Apps

View full text Add to dashboard Cite

This study is meant to characterize the serum proteome in a small geographical cluster of sporadic ALS subjects originating from a restricted geographical area and sharing the same environmental exposure, in a broader context of evaluating the relevance of environmental factors to disease onset, status, and progression. An Artificial Neural Network based software is used to compare the relative abundance of proteins identified as different (by means of bi-dimensional electrophoresis and mass spectrometry) in the serum proteome of patients and age-matched healthy controls. The patient's group is characterized by altered levels of acute phase reactants and of proteins involved in lipid homeostasis, along with over-representation of the APOE*4 allele. Characterization of the serum proteome in a small cluster of sporadic ALS patients, originating from a geographically restricted area with a high prevalence of the disease and evaluation of the results with software based on artificial neural networks, highlights the association of the relative abundance of some proteins (most notably, acute phase reactants and lipid homeostasis proteins) with the disease presence and status.

show abstract

Section: Discussionsupporting

confidence: 84%

Serum Proteome in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster

Benedetti

Gianazza

Banfi

et al. 2017

Proteomics Clinical Apps

View full text Add to dashboard Cite

show abstract

“…Yet, most authors agree that hypercholesterolemia, present as elevated levels of total cholesterol and LDL-c or a higher LDL-c/HDL-c ratio, associates with longer survival. This association, however, did not reach significance after adjusting for potential confounding demographic and clinical factors (37, 40, 43, 49–51).…”

Section: The Intriguing Case Of Cholesterolmentioning

confidence: 86%

Lipid Biomarkers for Amyotrophic Lateral Sclerosis

Aguilar

2019

Front. Neurol.

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease primarily characterized by the selective loss of upper and lower motor neurons. To date, there is still an unmet need for robust and practical biomarkers that could estimate the risk of the disease and its progression. Based on metabolic modifications observed at the level of the whole body, different classes of lipids have been proposed as potential biomarkers. This review summarizes investigations carried out over the last decade that focused on changes in three major lipid species, namely cholesterol, triglycerides and fatty acids. Despite some contradictory findings, it is becoming increasingly accepted that dyslipidemia, and related aberrant energy homeostasis, must be considered as essential components of the pathological process. Therefore, it is tempting to envisage dietary interventions as a means to counterbalance the metabolic disturbances and ameliorate the patient's quality of life.

show abstract

“…The link between lipid concentrations and survival remains an enigma in ALS. Nevertheless, a recent study has revealed that higher caloric intake improves survival and that low cholesterol may end up being deleterious in ALS patients ( Blasco et al, 2017 ). A phase III clinical trial evaluating the safety and the tolerance of KD in ALS patients fed through a gastrostomy tube has been conducted in the United States (clinicaltrials.gov NCT01016522), but results have not yet been published.…”

Section: Use Of Kd In Motor Dysfunctionmentioning

confidence: 99%

How Can a Ketogenic Diet Improve Motor Function?

Veyrat-Durebex

Reynier

Procaccio

et al. 2018

Front. Mol. Neurosci.

View full text Add to dashboard Cite

A ketogenic diet (KD) is a normocaloric diet composed by high fat (80–90%), low carbohydrate, and low protein consumption that induces fasting-like effects. KD increases ketone body (KBs) production and its concentration in the blood, providing the brain an alternative energy supply that enhances oxidative mitochondrial metabolism. In addition to its profound impact on neuro-metabolism and bioenergetics, the neuroprotective effect of specific polyunsaturated fatty acids and KBs involves pleiotropic mechanisms, such as the modulation of neuronal membrane excitability, inflammation, or reactive oxygen species production. KD is a therapy that has been used for almost a century to treat medically intractable epilepsy and has been increasingly explored in a number of neurological diseases. Motor function has also been shown to be improved by KD and/or medium-chain triglyceride diets in rodent models of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury. These studies have proposed that KD may induce a modification in synaptic morphology and function, involving ionic channels, glutamatergic transmission, or synaptic vesicular cycling machinery. However, little is understood about the molecular mechanisms underlying the impact of KD on motor function and the perspectives of its use to acquire the neuromuscular effects. The aim of this review is to explore the conditions through which KD might improve motor function. First, we will describe the main consequences of KD exposure in tissues involved in motor function. Second, we will report and discuss the relevance of KD in pre-clinical and clinical trials in the major diseases presenting motor dysfunction.

show abstract

A decrease in blood cholesterol after gastrostomy could impact survival in ALS

Cited by 9 publications

References 9 publications

Serum Proteome in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster

Serum Proteome in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster

Lipid Biomarkers for Amyotrophic Lateral Sclerosis

How Can a Ketogenic Diet Improve Motor Function?

Contact Info

Product

Resources

About