A decomposable silica-based antibacterial coating for percutaneous titanium implant

Wang, Jia; Wu, Guofeng; Liu, Xiangwei; Sun, Guanyang; Li, Dehua; Wei, Hongbo

doi:10.2147/ijn.s123622

Cited by 40 publications

(27 citation statements)

References 35 publications

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“…The loading efficiency and drug-loading content were calculated according to our previous studies. 25,26 To investigate the release behavior of CHX and silver ions, 100 mg of Ag-MSNs@CHX were dissolved in 100 mL of PBS solutions (pH =7.4 or 5.5) under ultrasonication. Then, the solution was transferred into a dialysis bag (molecular weight cutoff 5,000) on a shaking table at 37°C for 4 days.…”

Section: Drug Loading and The Release Of Chx And Silver Ionsmentioning

confidence: 99%

“…[19][20][21] Mesoporous silica nanoparticles (MSNs) have been used as prominent nanocarriers for bactericidal agents owing to their superior physicochemical properties and biocompatibility. [22][23][24][25][26][27] Conventionally, silver NPs are immobilized onto or embedded into MSNs to avoid the aggregation of silver NPs. 28,29 Thus, these nanocarriers slowly release silver ions, leading to enhanced efficacy against bacteria.…”

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confidence: 99%

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Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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Combination of chlorhexidine (CHX) and silver ions could engender synergistic bactericidal effect and improve the bactericidal efficacy. It is highly desired to develop an efficient carrier for the antiseptics codelivery targeting infection foci with acidic microenvironment. In this work, monodisperse mesoporous silica nanoparticle (MSN) nanospheres were successfully developed as an ideal carrier for CHX and nanosilver codelivery through a facile and environmentally friendly method. The CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) exhibited a pH-responsive release manner of CHX and silver ions simultaneously, leading to synergistically antibacterial effect against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli . Moreover, the effective antibacterial concentration of Ag-MSNs@CHX showed less cytotoxicity on normal cells. Given their synergistically bactericidal ability and good biocompatibility, these nanoantiseptics might have effective and broad clinical applications for bacterial infections.

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Section: Drug Loading and The Release Of Chx And Silver Ionsmentioning

confidence: 99%

mentioning

confidence: 99%

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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“…PLGA(Ag-Fe3O4)-coated dental implants [175] Sm 7 inhibited bacteria adherence Ag nanoparticles coated on titanium [179] E coli, Sa showed antibacterial effect and sustained release for 7 days Antibiotics doxycycline-coated abutment surfaces [180] Se 8 inhibited the bacterial growth; showed sustained release for least 2 weeks Tetracycline-containing fibers coated titanium implant [171] Pg, Fn 9 ,Pi 10 , Aa showed inhibition of biofilm and kept releasing for 3 days silica-gentamycin coated titanium implant [170] Sa showed antibacterial effect and sustained release for 14 days Tetracycline loaded nanofibers coated titanium implant [43] Aa, Fn, Pg, Pi Showed anti-bacterial effect Tetracycline loaded titanium [181] Pg showed antibacterial efficiency and sustained release for 15 days Cationic antibacterial agents chlorhexidine hexametaphosphate nanoparticles coated titanium [182] Sg demonstrated antibacterial effect and sustained release of soluble chlorhexidine for 99 days The PIXIT implant containing polysiloxane oligomers and chlorhexidine gluconate [183] Clinic trail controlled bacterial adhesion; reduced the bacterial species involved with long-term failure of dental implant Dimethylaminododecyl Methacrylate(DMADDM) coated dental implant [172] saliva-derived biofilm inhibited biofilm growth and regulated microecosystem Bioactive antibacterial agents Chitosan/P-HAP bi-layers coated titanium implant [184] Sg Demonstrated an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity * The bacterial model were showed in abbreviated form: 1 Such kinds of dual-functional DDS not only show antibacterial effects without affecting biocompatibility, but also help promote bone regeneration, which has excellent application potential. However, long-term drug release and multifunctional dental implant research are still limited.…”

Section: Coating Type Anti-bacterial Experiments Model * Resultsmentioning

confidence: 99%

“…They were incorporated into the titanium and abutments by electrodeposition technology. One-species [170], multi-species [171], saliva biofilms [172], and in vivo [173] test were applied for the antibacterial effect and biocompatibility. Other bioactive nanomaterials can also be coated with dental implants as carriers such as biodegradable and/or bioactive agents gelatin, chitosan, and hydroxylapatite, which can also help the bone regeneration.…”

Section: Dds For Peri-implantitismentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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“…[49] Shahi et al [50] immobilized tetracycline-containing fibers at the surface of implants obtaining a significant, although transient, antibacterial activity. [50] Wang et al [51] developed a silica-based gentamicin nanodelivery system cross-linked to oxidized titanium.…”

Section: Implant-dependent Factorsmentioning

confidence: 99%

A review on the prevention of inflammatory periimplant diseases

et al. 2019

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A decomposable silica-based antibacterial coating for percutaneous titanium implant

Cited by 40 publications

References 35 publications

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

A review on the prevention of inflammatory periimplant diseases

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