Although there is a longstanding tradition linking labor market risks and attitudes toward immigration, recent accounts downplay this dimension. Instead, it is argued that cultural rather than economic dimensions explain anti-immigrant attitudes. In this paper, I argue that the picture that emerges from this analysis is incomplete because it neglects that economic hardship can lead to cultural resentment toward immigrants. This article focuses on occupation-specific skills (OSS), which tend to shelter workers from labor market competition when the occupational labor market is tight but not when it is loose. I therefore argue that a deterioration of the occupational context has a stronger impact on individuals with high OSS. This implies that the most affected groups include Managers and Professionals. Empirically, I analyze how occupational deterioration, moderated by OSS, leads to more hostile attitudes toward immigrants on cultural grounds, using a variety of attitudinal surveys. Moreover, I show that occupational deterioration has a larger impact on perceived labor market risks and status loss for individuals with higher OSS.