A decision dilemma: Cushing syndrome during pregnancy

Darocas, M.; Ruiz, Nuria Martín; Bergoglio, M. T.; Cano, Antonio

doi:10.3109/01443615.2014.937329

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Some clinical manifestations of CS during pregnancy are quite similar to those of normal pregnancy, such as obesity, stretchmarks, lower extremity edema, and abnormal glucose tolerance, which are likely to be confused with pregnancy-induced hypertension or diabetes. The diagnosis of CS should be considered when the triad of hypertension, skin ecchymosis, and muscular atrophy appears 4 , 6 . In our opinion, “buffalo hump”, dorsal fat pad, is the most remarkable sign that can be differentiate CS from normal pregnancy because it cannot appear in average pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of High-risk Pregnant Women With Cushing Syndrome Caused by Adrenal Tumor

Zhao¹,

Alimu²,

Dai³

et al. 2021

CRSLS

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of High-risk Pregnant Women With Cushing Syndrome Caused by Adrenal Tumor

Zhao¹,

Alimu²,

Dai³

et al. 2021

CRSLS

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Cushing’s syndrome and pregnancy outcomes: a systematic review of published cases

et al. 2016

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Pregnancy in Cushing's syndrome (CS) is extremely rare due to the influence of hypercortisolism on the reproductive axis. Purpose of this study is to investigate whether the etiology of CS in pregnancy determines a different impact on the fetal/newborn and maternal outcomes. We performed a systematic review of cases published in the literature from January 1952 to April 2015 including the words "Cushing AND pregnancy". We included 168 manuscripts containing 220 patients and 263 pregnancies with active CS during pregnancy and with a history of CS but treated and cured hypercortisolism at the time of gestation. Adrenal adenoma was the main cause of active CS during pregnancy (44.1 %). Women with active CS had more gestational diabetes mellitus (36.9 vs. 2.3 %, p = 0.003), gestational hypertension (40.5 vs. 2.3 %, p < 0.001) and preeclampsia (26.3 vs. 2.3 %, p = 0.001) than those with cured disease. The proportion of fetal loss in active CS was higher than in cured CS (23.6 vs. 8.5 %, p = 0.021), as well as global fetal morbidity (33.3 vs. 4.9 %, p < 0.001). The predictors of fetal loss in active CS were etiology of hypercortisolism [Odds Ratio -OR-for pregnancy-induced CS 4.7 (95 % Confidence Interval-CI 1.16-18.96), p = 0.03], publication period [OR for "1975-1994" 0.10 (95 % CI 0.03-0.40), p = 0.001] and treatment during gestation (p = 0.037, [OR medical treatment 0.25 (95 % CI 0.06-1.02), p = 0.052], [OR surgical treatment 0.34 (95 % CI 0.11-1.06), p = 0.063]). The period of diagnosis of CS (before, during or after pregnancy) was the only predictor of overall fetal morbimortality [OR for diagnosis during pregnancy 4.66 (95 % CI 1.37-15.83), p = 0.014]. Patients with active CS, especially in pregnancy-induced CS, experienced more problems in pregnancy and had the worst fetal prognosis in comparison to other causes. Diagnosis of CS during pregnancy was also associated with worse overall fetal morbimortality. Both medical treatment and surgery during pregnancy appeared to be protective in avoiding fetal loss.

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A decision dilemma: Cushing syndrome during pregnancy

Cited by 2 publications

References 10 publications

Diagnosis and Treatment of High-risk Pregnant Women With Cushing Syndrome Caused by Adrenal Tumor

Diagnosis and Treatment of High-risk Pregnant Women With Cushing Syndrome Caused by Adrenal Tumor

Cushing’s syndrome and pregnancy outcomes: a systematic review of published cases

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