A decade of living lobar lung transplantation: recipient outcomes

Starnes, Vaughn A.; Bowdish, Michael E.; Woo, Marlyn S.; Barbers, Richard G.; Schenkel, Felicia A.; Horn, Monica V.; Pessotto, Renzo; Sievers, Eric M.; Baker, Craig J.; Cohen, Robbin G.; Bremner, Ross M.; Wells, Winfield J.; Barr, Mark L.

doi:10.1016/j.jtcvs.2003.07.042

Cited by 145 publications

(99 citation statements)

References 15 publications

(18 reference statements)

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“…Living-donor lobar lung transplantation (LDLLT) is an alternative to deceased-donor lung transplantation for severely ill patients with end-stage lung disease (1)(2)(3). This procedure has been used widely with good results because of a critical deficit in deceased-donor organs, particularly in Japan (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Right and Left Inverted Lobar Lung Transplantation

Chen

Miyamoto

Takemoto

et al. 2015

American Journal of Transplantation

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Adult recipients frequently withdraw from livingdonor lobar lung transplantation because of the small size of donor grafts. The right lower lobe is 120% larger than the left lower lobe. We developed a novel surgical technique in which an inverted right lower lobe graft can be transplanted into the left thorax. The first patient was a 43-year-old woman with end-stage idiopathic interstitial pneumonia. Her husband was the only eligible donor for living-donor lobar lung transplantation. His right lower lobe was estimated to provide 45% of the recipient's predicted forced vital capacity, which would provide the borderline function required for living-donor lobar lung transplantation. Since lung perfusion scintigraphy of the recipient showed a right-to-left ratio of 64:36, transplanting the right lower lobe graft into the left thorax and sparing the native right lung was considered the only treatment option. We simulated this procedure using three-dimensional models produced by a three-dimensional printer. In living-donor lobar lung transplantation, all anastomoses were performed smoothly as planned preoperatively. Because of the initial success, this procedure was performed successfully in two additional patients. This procedure enables larger grafts to be transplanted, potentially solving critical size matching problems in livingdonor lobar lung transplantation.

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Section: Introductionmentioning

confidence: 99%

Right and Left Inverted Lobar Lung Transplantation

Chen

Miyamoto

Takemoto

et al. 2015

American Journal of Transplantation

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“…Perioperative mortality of retransplantation was only 7.7% after LDLLT versus 42.3% after CLT. USC group reported that ventilator dependency and re-transplantation were significant risk factors of death in their 123 LDLLTs (13). In our experience, all 14 patients on a ventilator for as long as 7 months underwent successful LDLLT.…”

Section: Introductionmentioning

confidence: 62%

“…The USC group reported their long-term outcome on 123 LDLLT recipients including 39 children (13). Retransplantation and mechanical ventilation were found to be risk factors for perioperative mortality.…”

Section: Outcome Of Ldllt Recipientmentioning

confidence: 99%

Living Related Lung Transplantation

Date

2014

Regenerative Medicine Applications in Organ Transplantation

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“…[173][174][175][176] Living donors have been an important, although decreasing, source of organs for patients requiring kidney, pancreas after kidney, and liver transplants. 100 However, the latest US OPTN/SRTR report records only nine living donor lung transplants in the US since the implementation of the LAS and only two since 2008 through 2012.…”

Section: Living Related Lung Donationmentioning

confidence: 99%

Lung transplantation for chronic obstructive pulmonary disease

Liou¹,

Raman²,

Cahill³

2013

TRRM

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Abstract:Patients with end-stage chronic obstructive pulmonary disease (COPD) comprise the largest single lung disease group undergoing transplantation. Selection of appropriate candidates requires consideration of specific clinical characteristics, prognosis in the absence of transplantation, and likely outcome of transplantation. Increased availability of alternatives to transplantation for end-stage patients and the many efforts to increase the supply of donor organs have complicated decision making for selecting transplant candidates. Many years of technical and clinical refinements in lung transplantation methods have improved survival and quality of life outcomes. Further advances will probably come from improved selection methods for the procedure. Because no prospective trial has been performed, and because of confounding and informative censoring bias inherent in the transplant selection process in studies of the existing experience, the survival effect of lung transplant in COPD patients remains undefined. There is a lack of conclusive data on the impact of lung transplantation on quality of life. For some patients with end-stage COPD, lung transplantation remains the only option for further treatment with a hope of improved survival and quality of life. A prospective trial of lung transplantation is needed to provide better guidance concerning survival benefit, resource utilization, and quality of life effects for patients with COPD.

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A decade of living lobar lung transplantation: recipient outcomes

Cited by 145 publications

References 15 publications

Right and Left Inverted Lobar Lung Transplantation

Right and Left Inverted Lobar Lung Transplantation

Living Related Lung Transplantation

Lung transplantation for chronic obstructive pulmonary disease

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